Abstract 1524
Background
Disease stage is the most powerful prognostic factor in OSCC but is not accurate enough to identify highest risk patients. Other patient-related conditions as comorbidity add relevant prognostic value. We show the importance of the comorbidity assessment in contrast to other historic prognosis factors.
Methods
Retrospective review of patients with resectable OSCC from 2011 to 2014. Baseline pretreatment comorbidity data were collected according to ACE–27. Clinical, pathological, presurgical blood samples and treatment data were collected. Kaplan-Meier and Cox proportional hazards modeling were used to determine associations with OS (Overall Survival), DSS (Disease-Specific Survival) and DFS (Disease-Free Survival).
Results
Among 215 patients, median age was 67 years (range 32-96). Median follow-up was 31 months (1– 78). 74% suffered at least one previous comorbid condition. 3-year OS, DSS and DFS were 68%, 77% and 65%, respectively. The multivariable model is showed in the table. Suffering a severe comorbidity had the highest prognostic value, greater than present a locally advanced OSCC [HR = 6.24; 95%CI=2.08-18.67p< 0.001].Table: 1107P
Multivariable model
| Variable | HR | 95%CI | p |
|---|---|---|---|
| Low comorbidity | 2.61 | [0.95-7.21] | 0.006 |
| Moderate comorbidity | 3.17 | [1.24-8.11] | 0.02 |
| Severe comorbidity | 6.24 | [2.08-18.67] | <0.001 |
| Haemoglobin < 13.6 g/dL | 1.92 | [1.04-3.55] | 0.04 |
| Stage II | 2.57 | [0.87-7.58] | 0.009 |
| Stage III-IV | 4.10 | [1.15-14.67] | 0.03 |
| N0. Watchful waiting | 2.82 | [0.98 – 8.12] | 0.05 |
| Therapeutic neck disection | 2.57 | [1- 6.60] | 0.05 |
| PLR (platelets to lymphocytes ratio ) >66 | 3.98 | [0.88-17.93] | 0.07 |
| Age > 80 | 2.88 | [1.28-6.46] | 0.01 |
Conclusions
We described the account of comorbidity assessment as a prognosis factor of resectable OSCC. We provide the importance of additional clinical and easily accessible information to tumor stage, capable of discriminating prognostic risk factors in resectable OSCC.
Clinical trial identification
Legal entity responsible for the study
The Clinical research Ethics Committee of Aragón (CEIC-A).
Funding
Has not received any funding.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
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