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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

1524 - The importance of comorbidity assessment in patients with oral squamous cell carcinoma (OSCC). Could the Adult Comorbidity Evaluation – 27 (ACE-27) provide an additional information?

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Topics

Tumour Site

Head and Neck Cancers

Presenters

Ursula Jariod Ferrer

Citation

Annals of Oncology (2018) 29 (suppl_8): viii372-viii399. 10.1093/annonc/mdy287

Authors

U.M. Jariod Ferrer1, S. Blanco Sanfrutos2, M.A. Gavin Clavero1, T. Uson Bouthelier1, B. Nadal Cristobal1, I. Moral Saez1, I. Pajares Bernad3, A.I. Cisneros Gimeno4, J. Martinez Trufero3

Author affiliations

  • 1 Oral And Maxillofacial Surgery, Hospital Miguel Servet, 50009 - Zaragoza/ES
  • 2 Oral And Maxillofacial Surgery, Hospital Can Misses Ibiza, 07800 - Eivissa/ES
  • 3 Medical Oncology Department, Hospital Miguel Servet, 50009 - Zaragoza/ES
  • 4 Anatomy Department, University of Zaragoza, 50009 - Zaragoza/ES
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Resources

Abstract 1524

Background

Disease stage is the most powerful prognostic factor in OSCC but is not accurate enough to identify highest risk patients. Other patient-related conditions as comorbidity add relevant prognostic value. We show the importance of the comorbidity assessment in contrast to other historic prognosis factors.

Methods

Retrospective review of patients with resectable OSCC from 2011 to 2014. Baseline pretreatment comorbidity data were collected according to ACE–27. Clinical, pathological, presurgical blood samples and treatment data were collected. Kaplan-Meier and Cox proportional hazards modeling were used to determine associations with OS (Overall Survival), DSS (Disease-Specific Survival) and DFS (Disease-Free Survival).

Results

Among 215 patients, median age was 67 years (range 32-96). Median follow-up was 31 months (1– 78). 74% suffered at least one previous comorbid condition. 3-year OS, DSS and DFS were 68%, 77% and 65%, respectively. The multivariable model is showed in the table. Suffering a severe comorbidity had the highest prognostic value, greater than present a locally advanced OSCC [HR = 6.24; 95%CI=2.08-18.67p< 0.001].Table: 1107P

Multivariable model

VariableHR95%CIp
Low comorbidity2.61[0.95-7.21]0.006
Moderate comorbidity3.17[1.24-8.11]0.02
Severe comorbidity6.24[2.08-18.67]<0.001
Haemoglobin < 13.6 g/dL1.92[1.04-3.55]0.04
Stage II2.57[0.87-7.58]0.009
Stage III-IV4.10[1.15-14.67]0.03
N0. Watchful waiting2.82[0.98 – 8.12]0.05
Therapeutic neck disection2.57[1- 6.60]0.05
PLR (platelets to lymphocytes ratio ) >663.98[0.88-17.93]0.07
Age > 802.88[1.28-6.46]0.01

Conclusions

We described the account of comorbidity assessment as a prognosis factor of resectable OSCC. We provide the importance of additional clinical and easily accessible information to tumor stage, capable of discriminating prognostic risk factors in resectable OSCC.

Clinical trial identification

Legal entity responsible for the study

The Clinical research Ethics Committee of Aragón (CEIC-A).

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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