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Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

5062 - The frequency of primary cilia, CD8+ tumor infiltrating lymphocytes and PD-1 expression in renal cell carcinoma of clear-cell type

Date

20 Oct 2018

Session

Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

Topics

Translational Research

Presenters

Josef Dvorak

Citation

Annals of Oncology (2018) 29 (suppl_8): viii14-viii57. 10.1093/annonc/mdy269

Authors

J. Dvorak1, B. Rosova2, A. Filipova3, D. Hadzi Nikolov4, L. Dusek5, A. Rozsypalova6, J. Proks6, I. Richter7, B. Melichar8, T. Buchler1, R. Zachoval9, R. Matej2

Author affiliations

  • 1 Oncology, Thomayer University Hospital, 140 59 - Prague/CZ
  • 2 Pathology, Thomayer University Hospital, 15800 - Prague/CZ
  • 3 Radiobiology, Faculty of Military Health Sciences in Hradec Kralove, University of Defense in Brno, 50005 - Hradec Kralove/CZ
  • 4 Pathology, Regional Hospital, 280 02 - Kolin/CZ
  • 5 Institute Of Biostatistic And Analyses, Masaryk University Brno, 62500 - Brno/CZ
  • 6 Oncology, Thomayer University Hospital, 15800 - Prague/CZ
  • 7 Oncology, Regional Hospital, 460 01 - Liberec/CZ
  • 8 Oncology, University Hospital Olomouc, 77520 - Olomouc/CZ
  • 9 Urology, Thomayer University Hospital, 15800 - Prague/CZ
More

Resources

Abstract 5062

Background

Primary cilium (PC) is considered to represent a functional homologue of the immune synapse due to morphological and functional similarities in architecture. Both microtubule structures, i.e. primary cilia of cancer-associated fibroblasts and immune synapses between cytotoxic CD8+ tumor infiltrating lymphocytes (TILs) and antigen-presenting or cancer cells, are regularly found in varying amounts in the microenvironment of solid tumors. These could, in fact, represent two sides of the same coin. However, so far both parameters have not been evaluated simultaneously within the same group of patients.

Methods

The presence of PC in cells, programmed cell death protein-1 receptor (PD-1) expression and the frequency of intraepithelial CD8+ TILs was retrospectively evaluated in tumor tissue blocks of the resected specimens of the kidney in 104 patients with renal cell carcinoma of clear-cell type, 71 males and 33 females, with a median age of 64 years (range 38-82 years). Twenty-eight patients had stage I, 15 stage II, 31 stage III and 30 patients had stage IV tumor. Grade was as follows: grade 1 in 27 patients, grade 2 in 15 patients, grade 3 in 31 patient and grade IV in 30 patients.

Results

The median frequency of PC was 0.0028% (0-0,0465%). The frequency of intraepithelial CD8+ TILs was negative in 1 patient, <25% in 63, 26-50% in 29 and 26-50% in 11, respectively. The expression of PD-1 was <5% in 52 patients, 5-25% in 34 patients, 26-50% in 13 patients, 51-75% in 4 patients and 75% in 1 patient. During the follow-up, recurrence occurred in 42 patients and 43 patients died. Median PFS was 44% (95% CI: 34-67%) and median OS was 98% (95% CI: 84-117%).

Conclusions

The present study provides the first data on the potential association frequency of PC, PD-1 and CD8+ TILs in patients with renal cancer.

Clinical trial identification

Legal entity responsible for the study

MH CZ-DRO (TH, 0064190).

Funding

MH CZ-DRO (TH, 0064190) and Ministry of Defense of the Czech Republic - long-term organization development plan Medical Aspects of Weapons of Mass Destruction of the Faculty of Military Health Sciences, University of Defense.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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