Abstract 4678
Background
Lobectomy is the most performed surgical procedure for lung cancer, however, patients who are eligible to lobectomy undergo wedge resection. The purpose of this study is to compare the survival of patients who underwent wedge resection versus lobectomy.
Methods
Using SEER18 Registries Research Database, we collected the data of 638 patients diagnosed with lung cancer from 2010 to 2012. Out of these patients, 423 underwent wedge resection, while 156 had lobectomy. We assessed the prognostic value of age, sex, stage, laterality and primary site. Kaplan-Meier method was used for survival analysis.
Results
Patients with lung cancer who underwent lobectomy had significantly better 3-year relative survival rates 47.2% than those who underwent wedge resection (47.2% versus 26.7%, respectively, p-value = 0.044). Subgroup analysis revealed better survival rates among female patients and stage III lung cancer. However, no advantage was associated with specific age, laterality, or primary site.Table: 1816P
Comparison of 3-year relative survival rates between patients undergoing wedge resection vs lobectomy
| Variables | Wedge resection | Lobectomy | p-value |
|---|---|---|---|
| Sex Male Females | 20.2 33.3 | 33.5 64.4 | 0.000** |
| Stage I II III IV | - - 50.6% 26% | - 34.1% 52.2% 47.4% | 0011* |
| Age 20-39 40-59 60-79 >80 | 30.9% 27.4% 27.1% 22.6% | 66.9% 57.5% 42.3% 30.9% | 0.416 |
| Primary site Upper Lobe Middle Lobe Upper Lobe Lung, NOS | 24.1% 17.5% 29.6% 25.6% | 49.9% 46.9% 46.2% 44,9% | 0.934 |
| Laterality Right Left | 25.4% 28.3% | 49.7% 43.4% | 0.902 |
Statically significant at p-value ≤ 0.05.
**Highly significant at p-value ≤ 0.001.
Conclusions
Patients who underwent lobectomy were associated with better 3-year relative survival rate compared to wedge resection.
Clinical trial identification
Legal entity responsible for the study
Somia Alshafie.
Funding
Has not received any funding.
Editorial Acknowledgement
Inas Uthman.
Disclosure
All authors have declared no conflicts of interest.
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