Abstract 4039
Background
The aim of this study was to assess the prognostic significance of parameters derived from pretreatmentF-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) for patients with nasopharyngeal carcinoma (NPC) received intensity-modulated radiation therapy (IMRT). Furthermore, the functional information provided by PET/CT may offer the feasibility of biological conformality in tumor target delineation and dose planning.
Methods
We retrospectively reviewed 82 NPC patients who underwent pretreatment F-18 FDG PET/CT and received IMRT between 2010 and 2013. Maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) of the primary tumor were measured by F-18 FDG PET/CT. MTV might be viewed as a collection of absolute SUV values equal to or greater than a certain threshold on each axial image of PET/CT. The ROC curve was used to determine the appropriate cut-off point of SUVmax and MTV. The prognostic significance of MTV, SUVmax was assessed in the study. Meanwhile, the paper studies the relation between SUVmax, MTV, and primary tumor volume (PTV). Receiver operating characteristic (ROC) analysis was used to determine the optimal MTV cut-off value.
Results
Positive correlations between PTV and MTV, SUVmax and MTV were found. PTV, SUVmax, and MTV were significant predictors of survival. The 3-year progression-free survival (PFS) for SUVmax≤8.20 and SUVmax>8.20 were 91.1% and 73.0% (p = 0.027). With furthermore analysis, patients having tumor with lower MTV had higher 3-year PFS than patients having tumor with higher MTV. The percentage of the MTV5.0 in PTV was 14.66±15.75% (95%CI,11.20-18.13).
Conclusions
Our study indicated that PET/CT-derived parameters, SUVmax and MTV, are very important in assessing prognosis and making radiotherapy planning. Patients having tumor with lower MTV had higher 3-year PFS than patients having tumor with higher MTV. It is necessary to give a more aggressive treatment for patients with higher MTV. The MTV5.0 might be an appropriate quantitative definition of hypoxic sub-volumes for radiotherapy boost to improve the therapeutic effect.
Clinical trial identification
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
4784 - Tranilast inhibits TGF-beta-induced EMT and invasion/metastasis via the suppression of Smad4 in lung cancer cell lines.
Presenter: Koji Takahashi
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
767 - Integrin beta-like 1 overexpression stimulates invasiveness of ovarian cancer cells in vitro
Presenter: Alexander Cortez
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
938 - MiR-449a suppresses endometrial cancer invasion and metastasis by targeting NDRG1
Presenter: Lihua Qiu
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4866 - Cancer-associated fibroblasts-derived VEGFA mediates the migration of gastric cancer cells through VEGFR1
Presenter: xiaoxun Wang
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4934 - Risk prediction of metastasis through study of circulating tumor cells
Presenter: Panagiotis Apostolou
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3289 - First step to metastasis: miRNAome abnormalities impair cell-cell adhesion and facilitate detachment of breast cancer cells
Presenter: Volodymyr Halytskiy
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4110 - Extracellular matrix of normal brain tissue is affected by temozolomide during anti-glioblastoma treatment
Presenter: Alexandra Tsidulko
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1526 - Study of the activation of TLR receptors in neurospheres from glioblastoma cells in vitro
Presenter: David Albert Bellver
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4862 - 5-Fluorouracil induced up-regulation of exosomal PD-L1 causing immunosuppression in gastric cancer patients
Presenter: Zhang Min
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
635 - Thrombocytosis and leukocytosis: are they negative prognostic factors in solid tumours?
Presenter: Filip Kohutek
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract