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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

1035 - Short- and Long-term Outcomes of High Tie versus Low Tie with Lymph Node Dissection around the Inferior Mesenteric Artery in Sigmoid Colon or Rectal Cancer Surgery

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Topics

Surgical Oncology

Tumour Site

Colon and Rectal Cancer

Presenters

Xinxiang Li

Citation

Annals of Oncology (2018) 29 (suppl_8): viii150-viii204. 10.1093/annonc/mdy281

Authors

X. Li

Author affiliations

  • Colorectal Surgery, Fudan University Shanghai Cancer Center, 200032 - Shanghai/CN
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Resources

Abstract 1035

Background

Controversy is ongoing on the level of inferior mesenteric artery (IMA) ligation in sigmoid colon or rectal cancer surgery. In the present study, we aimed to reevaluate the mortality and morbidity especially for anastomotic leakage of low tie combined with lymph node dissection (LT+LND) around the inferior mesenteric artery compared with high tie (HT) in sigmoid colon or rectal cancer surgery using propensity score matching (PSM) analyses.

Methods

A total of 1895 patients with sigmoid colon or rectal cancer who underwent curative surgery from 2012 to 2017 in Fudan University Shanghai Cancer Center were recruited into this study. After PSM, LT+LND-and HT-matched patients were comparable. Ultimately, 277 patients were ligated at the origin of IMA and 277 patients experienced the preservation of left colic artery plus lymph node dissection around IMA. The survival outcomes and clinicopathological characteristics were reviewed from the database retrospectively.

Results

The median follow-up period was 13.7 months (range from 1 to 69 months). There were no differences in terms of postoperative complication rate and overall survival (OS) as well as disease-free survival (DFS). In the HT group and LT+LND group, the 3-year OS rates were 90.8% and 90.0%, respectively, whereas the 3-year DFS rates were 78.7% and 73.9%, respectively. Further, LT+LND was associated with prolonged operation time and less blood loss.

Conclusions

LT+LND seems to be less invasive and is not inferior to HT from the point of oncological safety. Further prospective studies and long-term follow-up data are needed.

Clinical trial identification

Legal entity responsible for the study

Xinxiang Li.

Funding

This work was supported by the National Natural Science Foundation of China (Grant NO. 81772599).

Editorial Acknowledgement

Disclosure

The author has declared no conflicts of interest.

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