Abstract 3654
Background
Sexual function and quality of life remain unexplored in long-term survivors of bilateral testicular cancer (TC). The aim was to investigate sexual function, fatigue, anxiety and depression in long-term survivors of bilateral TC (unilateral TC with contralateral germ cell neoplasia in situ (TC+GCNIS) or bilateral TC (BTC)).
Methods
Cross-sectional study of 2479 long-term TC survivors of whom 126 were treated with contralateral radiotherapy due to GCNIS, 93 were treated with bilateral orchiectomy due to BTC and 2260 had unilateral TC (reference group). Outcomes were assessed with validated questionnaires with a median time since diagnosis of 17 years (interquartile range (IQR) 12-23 years). Results in TC+ GCNIS and BTC were compared with the reference group. Adjustment was made for age and treatment for disseminated disease.
Results
The age-adjusted risk of anxiety was significantly increased in BTC survivors (odds ratio 1.7 (1.1-2.8) p = 0.002). Apart from increased risk of reduced motivation in survivors with TC+GCNIS there were no other significant differences between the groups. Limitations include the few cases with symptoms of depression.
Conclusions
Survivors of BTC had increased risk of anxiety but did not experience impairment of other aspects of quality of life. These results are of importance for evidence-based information on late effects for bilateral TC patients.
Clinical trial identification
Legal entity responsible for the study
Danish Testicular Cancer Group (Dateca).
Funding
Copenhagen University Hospital Rigshospitalet.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.