Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

1260 - Risk of secondary hematological malignancies and hematological toxicities in recurrent ovarian cancer patients treated with poly adenosine diphosphate ribose polymerase (PARP) inhibitors maintenance

Date

20 Oct 2018

Session

Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

Topics

Supportive Care and Symptom Management

Tumour Site

Ovarian Cancer

Presenters

Kyaw Thein

Citation

Annals of Oncology (2018) 29 (suppl_8): viii332-viii358. 10.1093/annonc/mdy285

Authors

K.Z. Thein1, A. Sultan1, M.H. Zaw2, M.M. Han3, R. Yendala1, M.M. Zin4, S. Awasthi1, N. D'Cunha1, F. Hardwicke1, C. Jones1

Author affiliations

  • 1 Hematology Oncology, Texas Tech University Health Sciences Center, 79430 - Lubbock/US
  • 2 Internal Medicine, The Brooklyn Hospital Center, Brooklyn/US
  • 3 Oncologic Emergency, The University of Texas MD Anderson Cancer Center, Houston/US
  • 4 Internal Medicine, Kingsbrook Jewish Medical Center, Brooklyn/US
More

Resources

Abstract 1260

Background

Most patients with advanced ovarian cancer, the eighth most common cause of cancer death in women worldwide, recur after they receive initial platinum-based chemotherapy. PARP inhibitors showed a synthetic lethality in cancer cells via specific DNA repair defects. Yet, the risk of secondary hematological malignancies (SHM) and hematological toxicities, remains substantial. We undertook a systematic review and meta-analysis of randomized controlled trials (RCT) to determine the risk of SHM and hematological toxicities.

Methods

MEDLINE, EMBASE databases and meeting abstracts from inception through March 2018 were queried. Phase III RCTs that mention any hematological malignancies and toxicities as adverse effects were incorporated in the analysis. Mantel-Haenszel (MH) method was used to calculate the estimated pooled risk ratio (RR) and absolute risk difference (RD) with 95% confidence interval (CI). Fixed effects model was applied.

Results

Three phase III RCTs with 1401 patients were eligible. The study arms used olaparib or niraparib or rucaparib while the control arms utilized placebo. The I2 statistic for heterogeneity was 16.86, and the heterogeneity X2 (Cochran’s Q) was 2 (P = 0.30), suggesting homogeneity. The SHM incidence was 12 (1.28%) in PARP inhibitors group vs 5 (1.07%) in control group. The RR for SHM was 1.14 (95% CI: 0.42 – 3.08, P = 0.79) and RD was 0.002 (95% CI: - 0.01 – 0.014, P = 0.72). The RR of all-grade side effects were as follows: anemia, 6.57 (95% CI: 4.64 – 9.30, p < 0.001); thrombocytopenia, 9.80 (95% CI: 6.19 – 15.50, p < 0.001); and neutropenia, 4.13 (95% CI: 2.79 – 6.12, p < 0.001). The RR of high-grade adverse effects were as follows: anemia, 28.85 (95% CI: 10.06 – 82.72, p < 0.001); thrombocytopenia, 28.74 (95% CI: 8.24 – 100.24, p < 0.001); and neutropenia, 5.90 (95% CI: 3.01 – 11.57, p < 0.001).

Conclusions

Patients on PARP inhibitors experienced a notable increase in the risk of all grades of hematological toxicities. However, there was no significant increase in the risk of secondary hematological malignancies in PARP inhibitors group. Long-term follow-up of these patients is required to determine the actual relation.

Clinical trial identification

Legal entity responsible for the study

Kyaw Zin Thein/ Texas Tech University Health Sciences Center.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.