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Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

5664 - Quality of life in newly diagnosed patients with cervical cancer in Brazil: results of EVITA study (EVA/LACOG 0215).

Date

20 Oct 2018

Session

Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

Topics

Supportive Care and Symptom Management

Tumour Site

Cervical Cancer

Presenters

Angélica Nogueira-Rodrigues

Citation

Annals of Oncology (2018) 29 (suppl_8): viii332-viii358. 10.1093/annonc/mdy285

Authors

A. Nogueira-Rodrigues1, A.C. de Melo2, A.F.D.C. Calabrich3, E. Cronenberger4, K.L. Torres5, F. Damian6, R. Cossetti7, C.R.A..S. De Azevedo8, A.J. da Fonseca9, Y. Nerón10, J.S. Nunes11, A. Lopes12, F. Thomé13, R. Leal14, G. Borges15, P.R.S. Nunes Filho16, F. Zaffaroni Caorsi17, R.D.S. Freitas18, G. Werutsky19, F.C. Maluf20

Author affiliations

  • 1 Medical School, Federal University of Minas Gerais, 30130-100 - Belo Horizonte/BR
  • 2 Clinical research Department, INCA - Instituto Nacional de Cancer, 20231-050 - Rio de Janeiro/BR
  • 3 Medical Oncology, Assistencia Multidisciplinar em Oncologia Clinic, Salvador/BR
  • 4 Medical Oncology, Centro Regional Integrado de Oncologia, Fortaleza/BR
  • 5 Medical Oncology, Fundação Centro de Controle de Oncologia do Estado do Amazonas, Manaus/BR
  • 6 Centro De Pesquisa Em Oncologia, Hospital São Lucas, Porto Alegre/BR
  • 7 Medical Oncology, Hospital Aldenora Bello, São Luis/BR
  • 8 Medical Oncology, Instituto de Medicina Integral Professor Fernando Figueira, Recife/BR
  • 9 Medical Oncology, Hospital Geral de Roraima, Boa Vista/BR
  • 10 Medical Oncology, Centro de Pesquisas Oncológicas, Florianópolis/BR
  • 11 Medical Oncology, Hospital Erasto Gaertner, Curitiba/BR
  • 12 Medical Oncology, Instituto Brasileiro de Controle do Câncer, São Paulo/BR
  • 13 Medical Oncology, Hospital São Vicente de Paulo, Passo Fundo/BR
  • 14 Medical Oncology, Hospital Universitário Walter Cantídio, Fortaleza/BR
  • 15 Medical Oncology, Clínica Neoplasias Litoral, Itajaí/BR
  • 16 Medical Fellow, Latin American Cooperative Oncology Group, Porto Alegre/BR
  • 17 Clinical research, Latin American Oncology Group, Porto Alegre/BR
  • 18 Oncology, Latin American Cooperative Oncology Group, Porto Alegre/BR
  • 19 Clinical research, Latin American Cooperative Oncology Group, Porto Alegre/BR
  • 20 Medical Oncology, Hospital Beneficencia Portuguesa of Sao Paulo, . - Sao Paulo/BR
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Resources

Abstract 5664

Background

Cervical cancer (CC) is the fourth most common malignancy worldwide and 85% of new cases are diagnosed in low and middle-income countries. CC impact women health quality of life (HQoL) although the association between socioeconomic factors and HQoL is not well described in the literature. We aim to evaluate HQoL in patients newly diagnosed with CC in Brazil.

Methods

This is a prospective, observational cohort study (EVITA) that included patients from 16 institutions in Brazil. Main eligibility criteria were age ≥18 years-old, newly diagnosed stage I to IV invasive CC. Data were collected during a medical visit and from medical charts. HQoL was assessed at baseline using EORTC QLQ-C30 and CX24 questionnaires. Educational level and household income were assessed as a continuous variable and categorized for this analysis as < 8y or > =9y and <1 or > =1 minimum wage, respectively. Student t test was used for comparisons between early (stages I and II) and advanced (stages III and IV) disease.

Results

A total of 631 patients were included from January 2016 to November 2017. Mean age at diagnosis was 49.3y (±13.9). Most patients had <8 years of formal education (69.5%), household income £ one minimum wage (20.9%) and were treated in the public health system (95.7%). Regarding stage at diagnosis, patients with early stage disease (I and II) displayed better physical functioning (88 vs 80; P < 0.001) and role functioning (72 vs 61; P = 0.0115) scores, while patients with advanced disease had worse fatigue (27 vs 39; P = 0.0114), pain (26 vs 43; P < 0.001), constipation (23 vs 35; P = 0.0072), sexual activity (90 vs 95; P = 0.008), symptom experience (18 vs 24; P = 0.0083) and sexual worry (24 vs 33; P = 0.0489) scores. Sexual worry was worse in patients with > =9 years of education (21 vs 32; P = 0.0022). Other quality of life measures were not different among educational level and household income subgroups.

Conclusions

This is the most comprehensive evaluation of HQoL in cervical cancer in Brazil. Our study found that patients with advanced stage at diagnosis had worse quality of life. In patients newly diagnosed CC socioeconomic factors were of limited association with HQoL.

Clinical trial identification

NCT02671071.

Legal entity responsible for the study

Latin American Cooperative Oncology Group.

Funding

Roche.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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