4489 - Quality of life evaluation in acute leukemia patients receiving induction chemotherapy

Background

Over the past decades, special attention has been paid to study of quality of life (QoL) indicators in hematological patients receiving chemotherapy (CT). Nowadays QoL is conceptually viewed as an important complement to traditional objective evaluation measures. Aim. To assess QoL in patients with acute leukemia (AL) depending on the presence of concomitant ischemic heart disease (IHD) during the induction CT.

Methods

Our study involved 83 patients with newly diagnosed AL, of which 19 were lymphoblastic, 64 – myeloid leukemia, aged 16-72, 43 (51.8%) men, 40 (48.2%) women, according to ECOG I-II. Patients received standard induction CT. According to concomitant IHD patients were divided into groups: I (n = 47) - AL without cardiological diseases; II (n = 36) - AL with concomitant IHD. Patients were evaluated using SF-36 questionnaire to calculate physical and mental health components before treatment and after 2 induction courses of CT reaching remission.

Results

The indicators of physical and mental QoL components in patients of both groups before CT were significantly lower compared with healthy respondents. After reaching the remission in patients of group I, all QoL parameters improved, with the exception of bodily pain and social functioning. The average physical status indicators in patients of groups I and II did not significantly change. At the same time, the psychological status of patients improved: in group I in 1.5 times (40.9±2.25 vs 27.1±2.77 before CT, p < 0.05), in group II - in 1.3 times (37.3±2.82 vs 28.3±2.37 before CT; p < 0.05). Minimum values of all scales after CT were characteristic for patients with concomitant IHD in group II. Differences between groups were not statistically significant in all scales, except for the index of physical activity (41.7±1.36 vs 46.6±2.02; p < 0.05). However, in comparison with the data of practically healthy respondents, QoL of patients with AL after CT remained significantly lower.

Conclusions

The QoL evaluation in patients with AL with comorbid IHD during induction CT is an important component of the management of oncological patients, which allows individualizing the approach to each patient in the presence of this type of syntropy.

Clinical trial identification

Legal entity responsible for the study

Ukrainian Medical Stomatological Academy.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.