Abstract 3737
Background
The utility of performing 18.FDG PET/CT in the tumor staging and as a clinical management tool in the post-12Th-week chemoradiotherapy (CRT) in patients (pts) harboring locally advanced squamous-cell carcinoima of head and neck (LASCCHN) has been established. The aim of this report is to evaluate the impact of incorporating a staging 18.FDG-PET/CT and post CRT, for pts harboring 7Thedition AJCC staged III-IVA/B treated in a single medical centre.
Methods
Patients harboring LASCCHN who underwent induction chemotherapy (IC) with triplet taxane-containing regimen followed by concurrent CRT were prospectively evaluated as part of the A.C. Camargo Cancer Center PET/CT trial. Our pts underwent three 18.FDG-PET/CT. First as a baseline, second after cycle-1 IC and third at 10 to 12 weeks after completion of CRT. Our primary objective was early 18.FDG-PET/CT tumor response assessment after cycle-1 IC, which has been reported elsewhere. Herein we report changes in clinical staging, radiotherapy and surgical management generated by baseline and post-therapy PET-CTs. All pts provided signed consent for trial participation.
Results
Between February 2010 and July 2013, 49 pts (41 oropharynx, 4 hypopharynx and 4 larynx) were recruited. Upstaging in neck lymph nodes were registered in 6 cases (12.2%): N0 to N1 in 2, N1 to N2b in 1, N1 to N2c in 1, N2a to N2c in 1, N2b to N2c in one. One patient harboring unilateral N3 had demonstrated bilateral lymph node disease. Downstaging N1 to N0 was registered in 2 pts. Suspected distant metastatic disease was registered in 2 cases (lung 1, bone 1). Primary occult tumor was identified in 3, and secondary synchronic colorectal tumor was diagnosed in one case. Radiotherapy planning changes were generated by detection of new regional metastatic lymph nodes or identification of primary tumor in 10 patients (20.4%). Post-radiotherapy 18.FDG PET/CT was able to detect residual lymph node disease and residual primary disease in 3 and 1 pts respectively.
Conclusions
These findings confirm the clinical utility of performing pre and post CRT 18.FDG PET/CT in pts harboring LASCCHN.
Clinical trial identification
Brazilian Clinical Trial Registry - ReBEC - RBR-9wwstd.
Legal entity responsible for the study
A.C. Camargo Cancer Center.
Funding
Has not received any funding.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
1159 - Molecular characterization and search for founding effects in Canarian families with Hereditary Breast and Ovarian Cancer Syndrome
Presenter: Elisenda Llabres Valenti
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3725 - Effect of the polymorphism rs2066844 of the NOD2 gene on colon cancer incidence in a high cardiovascular risk population. Modulation by gender
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3708 - Effect of the polymorphisms rs1476413, rs1801131, rs4846052 and rs6541003 of the MTHFR gene on prostate cancer in a high cardiovascular risk population
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5057 - Association of a genetic variant in cyclin-dependent kinase Inhibitor 2A gene with the increased risk of breast cancer
Presenter: Soodabeh Shahid Sales
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5970 - Investigating the role of HAT protein TIP60 in regulating functional dynamics of nuclear receptor PXR
Presenter: KARISHMA BAKSHI
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1360 - The role of downregulated SIRT3 expression in patients with hepatocellular carcinoma
Presenter: Hanhee Jo
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1634 - Prediction and Intervention of Colorectal Cancer Risk with Artificial Intelligent System
Presenter: Yang Ge
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4921 - Measuring the Efficiency of Cancer Care in Europe
Presenter: Rikard Althin
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1235 - Circulating cell-free DNA isolated from plasma of mesenteric veins predicts prognosis in stage II colorectal cancer patients
Presenter: Chih-Yung Yang
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5169 - _lonality of uterine carcinosarcoma as a factor of clinical prognosis.
Presenter: Natalia Levitskaya
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract