Abstract 3494
Background
About 5% of breast cancers are metastatic (MBC) at diagnosis and 20-30% of localized breast cancer become secondarily metastatic. Patients suffer from many detrimental symptoms related to metastasis and treatments. Only four intervention studies worldwide have focused on physical activity (PA) interventions in MBC patients. The ABLE study is designed to assess the feasibility of a 6-month PA intervention in MBC patients and the effects of PA on physical, biological, psychological and clinical parameters.
Methods
A cohort of 50 newly diagnosed MBC patients have been recruited in an unsupervised and personalized 6-month PA program. At baseline and 6 months, we assessed anthropometrics, functional tests, biological parameters (inflammation, oxidative stress), questionnaires-based PA, quality of life, & fatigue, and tumor progression. Patients have worn a PA tracker which served both as a tool to record their own behaviour and maintain exercise adherence.
Results
The recruitment rate was at 94%. At baseline, participants’ age was 54.7 years (SD 10.4), BMI was 25.9kg/m² (5.7). Significant increase in distance during 6MWT (10.0%), extension force of the quadriceps (20.3%) and significant decrease of weight (2.0%), BMI (2.3%) and hip circumference (2.4%) were observed after the completion of the program. Mean walking steps during 6 months were 4799 per day.
Conclusions
The high recruitment rate shows the willingness of MBC patients to participate in this type of program. Preliminary data confirmed the need and desire of a PA intervention in the MBC population. This unsupervised PA program may encourage patients to maintain a long term physically active lifestyle.
Clinical trial identification
NCT03148886.
Legal entity responsible for the study
Centre Léon Bérard.
Funding
Cancéropole Lyon Auvergne Rhône Alpes, National Cancer League, Odyssea and Activ'RA.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.