Abstract 2762
Background
The induction chemotherapy (ICT) with triweekly TPF had been considered as an effective treatment in locally advance squamous cell carcinoma of head and neck (SCCHN). However, the treatment needs inpatient care and may have more toxicities for Asian patients. We conducted a phase 2 study of alternative biweekly TPFL as induction chemotherapy and evaluated the outcome and toxicities.
Methods
Patients with locally advanced SCCHN were enrolled in the study. Induction chemotherapy with Docetaxel 50mg/m2, cisplatin 50mg/m2, 5-fluorouracil 2500 mg/m2 and leucovorin 250 mg/m2 was administered biweekly for six cycles, followed by local treatment including concurrent chemoradiotherapy, bio-radiotherapy or surgery plus adjuvant RT. Our primary endpoint is response rate after ICT.
Results
Total 58 patients were enrolled in the study from June 2014 to September 2015. The median age is 53 years (from 28 to 69 y/o). The patients’ characteristics was mentioned as: primary site of oral cavity/oropharynx/hypopharynx: 18/25/15; stage IVa/IVb: 35/23; male /female: 54/4; performance status ECOG 0-1/2:57/1. In the oropharyngeal cancer patients neither p16 nor HPV16 status was not studied. Of those 58 patients, 56 patients received at least 4 cycles of chemotherapy. The overall response rate after ICT was 89.6 % (CR: 31% PR: 58.6%). Two patients escaped during induction chemotherapy. Grade 3/4 neutropenia was 25/9%; grade 3/4 mucositis was 1.7%; grade 3/4 diarrhea was 1.7%. Infection rate was 19%. The response rate after following treatment was 75 % (CR: 66.0%, PR: 9.0 %) The median follow-up time was 31.8 months. The overall 3 years PFS/OS was 34.3 %/56.1%. Local recurrence rate was 29.3% and distant metastasis rate was 10.3%. Six patients had second primary tumor. (10.3%) The 3 years PFS of patients with CR/PR were 59.3%/25.5%. The 3 years OS of patients with CR/PR were 81.7%/49.1%.
Conclusions
Biweekly TPFL induction chemotherapy has excellent response rate in locally advanced SCCHN. In addition, the grade 3/4 adverse event was acceptable. The patients achieved CR after induction chemotherapy had very good outcomes.
Clinical trial identification
CMUH103-REC2-038.
Legal entity responsible for the study
Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital.
Funding
Sanofi, Taiwan branch.
Editorial Acknowledgement
None
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
1159 - Molecular characterization and search for founding effects in Canarian families with Hereditary Breast and Ovarian Cancer Syndrome
Presenter: Elisenda Llabres Valenti
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3725 - Effect of the polymorphism rs2066844 of the NOD2 gene on colon cancer incidence in a high cardiovascular risk population. Modulation by gender
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3708 - Effect of the polymorphisms rs1476413, rs1801131, rs4846052 and rs6541003 of the MTHFR gene on prostate cancer in a high cardiovascular risk population
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5057 - Association of a genetic variant in cyclin-dependent kinase Inhibitor 2A gene with the increased risk of breast cancer
Presenter: Soodabeh Shahid Sales
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5970 - Investigating the role of HAT protein TIP60 in regulating functional dynamics of nuclear receptor PXR
Presenter: KARISHMA BAKSHI
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1360 - The role of downregulated SIRT3 expression in patients with hepatocellular carcinoma
Presenter: Hanhee Jo
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1634 - Prediction and Intervention of Colorectal Cancer Risk with Artificial Intelligent System
Presenter: Yang Ge
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4921 - Measuring the Efficiency of Cancer Care in Europe
Presenter: Rikard Althin
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1235 - Circulating cell-free DNA isolated from plasma of mesenteric veins predicts prognosis in stage II colorectal cancer patients
Presenter: Chih-Yung Yang
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5169 - _lonality of uterine carcinosarcoma as a factor of clinical prognosis.
Presenter: Natalia Levitskaya
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract