Objective: Initial nidus tumor infiltration is often revealed in patients with advanced breast cancer. In such cases, all treatment is focused on improvement of the quality of life.
Special mixture of Linimentam Synthomycin 10% (25 gr) + Tegafur (Ftorafur) 800 mg was prepared for anti inflammatory and tumor therapy. The mixture was used in bandaging of breast tumor infiltration in 99 patients for 10 days (interval - 20 days). Tumor infiltration in 84 patients -15 cm, in 15 patients > 30 cm. In 3 cases double-sided process was observed. All the patients had low hematological indicator and KPS (40,0 %).
After II course of treatment: significant improvement of dynamics of tumor infiltration in 49 (49,5%) patients (reduction of hyperemia, pain syndrome, itching, temperature, etc). After the III-IV courses: wound cleansing from purulent, formation of granulation areas and improvement of the quality of life in 10 patients (Tumor reduction and full epithelization in 10 (10,1%) patients enabling sanitation of mastectomy). Worsening of condition - in 18 (18.2%), stabilization in 71 (71.7%) patients. After the IV course of local therapy tumor infiltration was reduced by 9 cm in average (Maximum effect was seen in patients with infiltration of 15 cm) KPS average indicator improved from 40,0% to 53,4% (p < 0,05).
1. Administration of Synthomycin 10% (25 gr) + Tegafur (Ftorafur) 800 mg for local chemotherapy and anti – inflammatory therapy of breast cancer tumor infiltration contributes to reduction of hyperemia, temperature reaction, itching, suppuration, size of nidus, pain syndrome and accordingly improvement of the quality of life (KPS has improved from 40,0% to 53,4%; 2. Practically there are no side effects upon a local chemotherapy of breast.
Clinical trial identification
Legal entity responsible for the study
Tbilisi State Medical University (Georgia).
Has not received any funding.
All authors have declared no conflicts of interest.