Abstract 4333
Background
Fat grafting (FG) has become widely used in breast reconstruction after breast cancer (BC). FG might express protumorigenic factors or alter radiological aspect of the breast, raising some concerns on its oncological safety. The aim of the study was to describe clinical outcome of patients (pts) undergoing FG.
Methods
Records of 424 pts who underwent FG between 2010 and 2017 at the Plastic Surgery Dept. of Padova University were reviewed. Pts without invasive BC or not followed at Istituto Oncologico Veneto were excluded, leaving 206 pts for analysis. Cumulative Incidence of relapse was calculated from first FG. Association between clinico-pathological factors and relapse was explored.
Results
Patients were mostly post-menopausal (n = 115, 56%) and the majority had HR+/HER2- BC (n = 134, 65%). Eight pts (4%) were BRCA-mut carriers. Disease stage at diagnosis was: I (42%), II (34%), III (24%). Median interval from surgery to first FG was 23 months (range 0-257). 336 FG interventions were performed (median per patient: 1, range 1-9). At median follow-up of 38.9 months, 35 pts relapsed (10 locoregional, 25 distant relapses). Cumulative Incidence of relapse according to clinico-pathological subgroups is reported in the table. Semestral hazard rates of relapse in the three years after FG were: 0.010, 0.053, 0.034, 0.007, 0.039, and 0.038, respectively. 59 pts (29%) underwent additional breast imaging over standard recommendation (range 1-6 per patient), and 40 (20%) pts underwent breast biopsies (range 1-4, 10 confirmed a local recurrence).Table: 256P
| Clinicopathological factors | Number of patients (%) | 3-years cumulative incidence of relapse | Hazard Ratio (95% CI) | |
|---|---|---|---|---|
| HR status | HR negative | 26 (13%) | 13% | ref |
| HR positive | 170 (87%) | 16% | 1.57 (0.47-5.18) | |
| HER2 status | HER2 positive | 46 (24%) | 10% | ref |
| HER2 negative | 143 (76%) | 16% | 1.93 (0.74-2.05) | |
| Stage at diagnosis | Stage I | 81 (42%) | 11% | ref |
| Stage II | 67 (34%) | 17% | 2.84 (1.06-7.62) | |
| Stage III | 47 (24%) | 23% | 4.42 (1.68-11.63) | |
| Interval from surgery to first FG | >2 years | 99 (48%) | 16% | ref |
| <2 years | 107 (52%) | 17% | 1.07 (0.55-2.08) | |
| Type of breast surgery | Mastectomy | 180 (87%) | 15% | ref |
| Conservative | 26 (13%) | 25% | 1.53 (0.63-3.69) | |
| Overall Population | 206 (100%) | 17% | - |
Conclusions
This study describes a not negligible rate of recurrence in BC pts receiving FG, especially in stage III and conservative surgery pts. High risk of relapse in the first years after FG might suggest a potential relation between the procedure and events. Moreover, a significant proportion of pts underwent additional breast imaging and biopsies, which can adversely affect quality of life. A careful discussion in multidisciplinary setting is crucial for proper pts selection.
Clinical trial identification
Legal entity responsible for the study
Valentina Guarneri.
Funding
Has not received any funding.
Editorial Acknowledgement
No editorial assistance was provided by a third party for the abstract.
Disclosure
All authors have declared no conflicts of interest.
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