Abstract 3151
Background
Therapeutic strategies for treating breast cancer differ according to molecular subtype. We investigated whether dedicated breast PET (DbPET), a high-resolution molecular breast imaging system, could stratify breast cancer by subtype.
Methods
We included 390 patients with invasive breast cancer who underwent ring-type DbPET between January 2016 and March 2018. The association between SUVmax and various tumor characteristics such as size, nuclear grade, estrogen receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, and Ki-67 labeling index, were assessed. Tumor subtypes were classified as luminal A-like, luminal B-like, ER+/HER2+, ER-/HER2+, or triple negative on the basis of the St. Gallen International Expert Consensus.
Results
The median patient age was 57 years, the median tumor size was 1.5 cm, and the median SUVmax on DbPET was 6.9. The number of patients with each subtype was luminal A-like in 113, luminal B-like in 185, ER+/HER2+ in 40, and ER-/HER2+ in 12, and triple negative in 40 patients. SUVmax significantly correlated with tumor size (P < 0.001), nuclear grade (P < 0.001), ER status (P = 0.004), HER2 status (P < 0.001), and Ki-67 labeling index (P < 0.001). The median SUVmax values of the luminal A-like, luminal B-like, ER+/HER2+, ER-/HER2+, and triple negative subtypes were 4.6, 8.2, 9.5, 16.1, and 10.4, respectively (Table, all values of P < 0.001 relative to luminal A-like). Thus, DbPET distinguished luminal A-like tumor subtype from other subtypes.Table: 203P
| SUVmax on dedicated breast PET according to molecular subtypes. | ||
|---|---|---|
| Subtypes | Median SUVmax (IQR) | P value reffered to luminal A-like |
| Luminal A-like | 4.6 (3.0-6.8) | |
| Luminal B-like | 8.2 (4.6-12.4) | < 0.001 |
| ER+/HER2+ | 9.5 (5.5-16.6) | < 0.001 |
| ER-/HER2+ | 16.1 (7.5-20.2) | < 0.001 |
| Triple negative | 10.4 (4.2-17.0) | < 0.001 |
Conclusions
DbPET can be used to classify breast cancer into molecular subtypes, which may help determine the necessity of adjuvant chemotherapy. SUVmax, as assessed on DbPET, may thus contribute to the selection of proper therapeutic strategies in invasive breast cancer.
Clinical trial identification
Legal entity responsible for the study
Hiroshima University Hospital.
Funding
Has not received any funding.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
2595 - Real-Life Utilization of Genomic testing for invasive Breast Cancer patients in Italy and France reduces Chemotherapy Recommendations
Presenter: Sandro Barni
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
2343 - Benefit of adjuvant chemotherapy in hormone receptor-positive, HER2-negative, invasive lobular carcinoma of the breast
Presenter: Alexandre De Nonneville
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
2990 - Baseline lymphocyte counts predict distant recurrence in early breast cancer
Presenter: Gun Min Kim
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4532 - A propensity score analysis exploring the impact of the addition of adjuvant chemotherapy (aCT) to hormone therapy (aHT) in a multi-center series of resected luminal early stage pure Invasive Lobular Breast Carcinoma (ILC).
Presenter: Luisa Carbognin
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
2344 - Benefit of Adjuvant Systemic Therapies in HR+ HER2- pT1ab Node-Negative Breast Carcinomas
Presenter: Alexandre De Nonneville
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
3525 - Anti-proliferative effect of oral metronomic vinorelbine in PAM50 Luminal/HER2-negative early breast cancer (SOLTI-1501 VENTANA): an open-label, randomized, three-arm, multicenter, window-of-opportunity study
Presenter: Aleix Prat
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
3908 - Clinicopathologic significance of androgen receptor expression and discordant receptor status during progression in breast cancer
Presenter: Chan Heun Park
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4075 - The outcomes of early breast cancers utilizing the Oncotype Dx Recurrence score (RS) instead of Clinico-pathological (CP) factors for prognostic risk assessment: A Single Institution Experience
Presenter: Adhar Alsayed
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
738 - Circulating tumor cells as a prognostic marker in non metastatic breast cancer patients.
Presenter: Summar Elmorshidy
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4942 - Analytical validation of OncoMasTR, a multigene test for predicting risk of distant recurrence in hormone receptor-positive early stage breast cancer
Presenter: Tony Loughman
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract