Abstract 2078
Background
Previous works in molecular portraits of cancer have shown differences by ages with the accumulation of somatic mutations, suggesting that older patients may have aged specific genomic profiles. However, there is a lack of data concerning genomic alterations in metastatic older patients. We aimed at analyzing the clinical and pathological characteristics and outcomes by genomic alterations of older patients enrolled in MOSCATO-01 trial.
Methods
We retrospectively collected data from MOSCATO-01 trial from all patients over > 70 years old enrolled from November 2011 to March 2016 and performed a descriptive analysis of this sub group of patients with advanced solid tumor.
Results
Among the 1035 patients enrolled in the MOSCATO trial, 85 patients (8,2%) over 70 years old were included, with a median age of 74 (range 71-86). Urologic cancers were the most frequent cancer. All tumor biopsies were performed and a molecular portrait was obtained in 66 patients (77.6%). Almost 40 different molecular alterations were identified. An actionable molecular alteration was identified in 46 patients (54%). Among them, 13 patients had ≥ 2 (range 1-5) actionable targets. The most frequent alteration pathways were: Pi3K (21%), NOTCH (11,3%), FGF and FGFR mutation (both 9.7%), PTEN (6,5%), FBXW7, MDM2 and EGFR (4,8% each). A total of 23 (27%) patients were treated with a targeted therapy matched to a genomic alteration, and 15 of them were enrolled in phase 1 or 2. The PFS2/PFS1 ratio was >1.3 in 31.8 % of the patients (7/22, one missing data). Among the 46 patients with actionable molecular alteration, median overall survival was better in the group of patient with matched therapy (18.4 vs 5.4 months, p = 0,07 NS).
Conclusions
The genomic profile > 70 years old is feasible in advanced geriatric malignancies and can lead to a better understanding in the biology of cancer among the elderly and could improve outcomes with molecular target agents.
Clinical trial identification
MOSCATO 01 (NCT01566019).
Legal entity responsible for the study
Christophe Massard.
Funding
Gustave Roussy.
Editorial Acknowledgement
Disclosure
L. Verlingue: Consultant: Adaptherapy. A. Hollebecque: Honoraria: Merck Serono; Consulting: Amgen; Expenses: Amgen, Servier. J-C. Soria: Employement and ownership: AstraZeneca; Honoraria and consulting: AstraZeneca, BMS, Pfizer, Roche, Sanofi, Pierre Fabre. C. Massard: Other relationship: Amgen, Astellas Pharma, AstraZeneca, Bayer, Celgene, Genentech, Ipsen, Novartis, Pfizer, Roche, Sanofi, Orion Corporation, Lilly Pharma, Janssen Inc. Pharmaceutical. All other authors have declared no conflicts of interest.
Resources from the same session
5877 - TCR beta chain convergence defines the tumor infiltrating T cell repertoire of melanoma and non-small cell lung carcinoma.
Presenter: Timothy Looney
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
3212 - PI3K inhibition and modulation of immune and tumor microenvironment markers by copanlisib in patients with non-Hodgkin's lymphoma or advanced solid tumors
Presenter: Ahmad Awada
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
3574 - Pan-squamous genomic profiling stratified by anatomic tumor site and viral association
Presenter: Meagan Montesion
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
4113 - Toward the Standardization of Bioinformatics Methods for the Accurate Assessment of Tumor Mutational Burden (TMB)
Presenter: Han Chang
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
4468 - Prediction of primary resistance to anti-PD1 therapy (APD1) in 2nd line NSCLC
Presenter: Egbert Smit
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
4570 - Immunomodulatory germline variation impacts the development of multiple primary melanoma (MPM).
Presenter: Robert Ferguson
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
1169 - Leukocyte telomere length and recurrence risk after EGFR-TKIs therapy in patients with advanced lung adenocarcinoma
Presenter: Ming Yang
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
1707 - Gene embedding: a novel machine learning approach to identify gene candidates related to immunotherapy responsiveness
Presenter: Chi Tung Choy
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
2123 - Common and rare DPYD variants are predictive for 5FU/capecitabine (5FU) toxicity: The MRC COIN and COIN-B trials
Presenter: Ayman Madi
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
5671 - The landscape of NTRK fusions in Chinese solid tumor patients
Presenter: Qi Ling
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract