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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

5439 - Mesenteric Vs. Antimesenteric Colorectal Cancer. A Single Center Study.

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Topics

Tumour Site

Colon and Rectal Cancer

Presenters

Keun Hee Lee

Citation

Annals of Oncology (2018) 29 (suppl_8): viii150-viii204. 10.1093/annonc/mdy281

Authors

K.H. Lee1, W.R. Kim2, J.W. Kim3

Author affiliations

  • 1 Department Of Surgery, Bundang Cha Medical Center, 13496 - Seongnam/KR
  • 2 Surgery, CHA Bundang Medical Center, Seongnam/KR
  • 3 Surgery, Cha university, Gyunggi/KR
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Resources

Abstract 5439

Background

We investigated the possible correlation between the prognosis and circumferential location of the tumor according to the cancer involvement on the mesenteric side. This study is based on the hypothesis that mesenteric tumors, which are closer to blood and lymphatic vessels, could spread more aggressively and rapidly compared to the antimesenteric tumors.

Methods

We reviewed the retrospectively collected data of 251 patients treated during the period of October 2008 to May 2012. 162 patients with mesenteric side involving tumors were included in the mesenteric group, and 89 patients with antimesenteric tumors were included in the antimesenteric group. The analyzed information included age, gender, location, size of the main lesion, extent of lymph node metastasis, pathologic features, metastasis, complication, TNM stage, recurrence and 5-year survival. We retrospectively studied the survival of patients by examining of our 5-year follow-up archive. Data were analyzed using Pearson-Chi square test and Kaplan-Meier curve analysis.

Results

There was no statistical difference between the two groups regarding age, gender, location, extent of lymph node metastasis, pathologic features, complication, and TNM stage. The size of the main tumor was statistically larger in the mesenteric group compared to the antimesenteric group. (P value = 0.03) The mesenteric group showed statistically higher rate of distant metastasis and carcinomatosis than the antimesenteric group. (P value = 0.02) In addition, the mesenteric group showed lower 5-year survival rate than the antimesenteric group.

Conclusions

In conclusion, mesenteric tumors have significantly larger size of main tumor, higher rate of distant metastasis and worse 5-year survival than antimesenteric tumors. This difference implies that colorectal cancers should be regarded differently according to the circumferential location and more careful follow up is necessary with mesenteric side involving colorectal cancer patients.

Clinical trial identification

Legal entity responsible for the study

Jong Woo Kim.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

The author has declared no conflicts of interest.

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