Abstract 3389
Background
Epstein-Barr virus (EBV)-related Nasopharyngeal carcinoma (NPC) is a highly chemo-radiosensitive cancer. However, when relapsing without surgical or reirradiation options, NPC carries a dismal prognosis; survival >2 years being reported in 7-14% metastatic pts (1,2). We have previously achieved disease control using autologous EBV-specific cytotoxic T lymphocytes (CTL) in refractory/relapsed pts following conventional treatments (3). The aim of the present study was to evaluate outcomes in pts receiving T-cell therapy after first line chemotherapy (CT) for recurrent disease.
Methods
Sixteen patients (13 males, median age 41 yrs) with metastatic (n = 12; 7/12 with visceral metastasis, and 5/12 with bone and nodes lesions) or locally recurrent (n = 4) NPC received 2 administrations of EBV-specific CTL at a total cell dose/infusion of 1.5-3 x 108, following completion of first line CT. The best response after first-line CT had been progressive disease (PD) in 4 pts, stable disease (SD) in 3, partial response (PR) in 5 and complete response (CR) in 4.
Results
No severe adverse events were recorded, following CTL therapy. Among patients in CR after first-line CT, 3 remain in CR at 58, 76 and 77+ months, while one patient relapsed, but attained a long-lasting CR after treatment with 2nd-line CT. In the 12 patients treated with persistent disease (PR, SD, PD), the best response observed after CTL therapy, in some cases (3/12) associated with 1subsequent line of CT or radiotherapy, was PD in 8 patients, and CR (range 39-78+ months) in 4. At a median follow-up of 64 months, 8/16 patients are alive with no evidence of disease. Among the factors associated with positive outcome are response to first-line CT, and metastatic disease with limited tumor burden.
Conclusions
EBV-specific CTL therapy administered following first line CT for recurrent NPC, is safe and associated with remarkable clinical benefit in some patients, including long-lasting CR.
Clinical trial identification
Legal entity responsible for the study
Fondazione IRCCS Policlinico San Matteo Pavia.
Funding
Fondazione IRCCS Policlinico San Matteo, Ricerca Corrente RCR.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
1159 - Molecular characterization and search for founding effects in Canarian families with Hereditary Breast and Ovarian Cancer Syndrome
Presenter: Elisenda Llabres Valenti
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3725 - Effect of the polymorphism rs2066844 of the NOD2 gene on colon cancer incidence in a high cardiovascular risk population. Modulation by gender
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
3708 - Effect of the polymorphisms rs1476413, rs1801131, rs4846052 and rs6541003 of the MTHFR gene on prostate cancer in a high cardiovascular risk population
Presenter: Judith Begona Ramirez Sabio
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5057 - Association of a genetic variant in cyclin-dependent kinase Inhibitor 2A gene with the increased risk of breast cancer
Presenter: Soodabeh Shahid Sales
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5970 - Investigating the role of HAT protein TIP60 in regulating functional dynamics of nuclear receptor PXR
Presenter: KARISHMA BAKSHI
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1360 - The role of downregulated SIRT3 expression in patients with hepatocellular carcinoma
Presenter: Hanhee Jo
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1634 - Prediction and Intervention of Colorectal Cancer Risk with Artificial Intelligent System
Presenter: Yang Ge
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
4921 - Measuring the Efficiency of Cancer Care in Europe
Presenter: Rikard Althin
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
1235 - Circulating cell-free DNA isolated from plasma of mesenteric veins predicts prognosis in stage II colorectal cancer patients
Presenter: Chih-Yung Yang
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract
5169 - _lonality of uterine carcinosarcoma as a factor of clinical prognosis.
Presenter: Natalia Levitskaya
Session: Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology
Resources:
Abstract