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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

946 - Influenza vaccine effectiveness among cancer patients: a population-based study using health administrative and laboratory testing data from Ontario, Canada

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Topics

Bioethical Principles and GCP

Tumour Site

Presenters

Phillip Blanchette

Citation

Annals of Oncology (2018) 29 (suppl_8): viii562-viii575. 10.1093/annonc/mdy297

Authors

P. Blanchette1, H. Chung2, K.I. Pritchard3, C. Earle2, M. Campitelli2, N. Crowcroft4, J. Gubbay4, T. Karnauchow5, K. Katz6, A. McGeer7, D. McNally5, D. Richardson8, S. Richardson9, L. Rosella2, A. Simor10, M. Smieja11, G. Zahariadis12, A. Campigotto13, J. Kwong2

Author affiliations

  • 1 Medical Oncology, London Regional Cancer Program, University of Western Ontario, N6A 4L6 - London/CA
  • 2 Epidemiology, Institute of Clinical Evaluative Sciences, Toronto/CA
  • 3 Medical Oncology, Sunnybrook Odette Cancer Center, M4N 3M5 - Toronto/CA
  • 4 Epidemiology, Public Health Ontario, Toronto/CA
  • 5 Laboratory Medicine And Pathology, Children's Hospital of Eastern Ontario, Ottawa/CA
  • 6 Laboratory Medicine And Pathology, North York General Hospital, Toronto/CA
  • 7 Laboratory Medicine And Pathology, Mount Sinai Hospital, Toronto/CA
  • 8 Infectious Disease, William Osler Heath Centre, Toronto/CA
  • 9 Laboratory Medicine And Pathology, The Hospital for Sick Children, Toronto/CA
  • 10 Infectious Disease, Sunnybrook Health Sciences Centre, Toronto/CA
  • 11 Laboratory Medicine And Pathology, McMaster University, Hamilton/CA
  • 12 Laboratory Medicine And Pathology, Newfoundland and Labrador Public Health Laboratory, St John's/CA
  • 13 Laboratory Medicine And Pathology, London Health Sciences Centre, London/CA
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Resources

Abstract 946

Background

Seasonal influenza vaccination is recommended for cancer patients despite concerns that disease- or treatment-associated immunosuppression may decrease vaccine effectiveness (VE). The objective of this study was to evaluate VE against laboratory-confirmed influenza among cancer patients.

Methods

We conducted an observational test-negative design study of previously diagnosed cancer patients aged ≥18 years who were tested for influenza during the 2010-11 to 2015-16 influenza seasons in Ontario, Canada. We linked individual-level cancer registry, respiratory virus testing, and health administrative data. Vaccination status was determined from physician and pharmacist billing claims. We used multivariable logistic regression to estimate VE, adjusting for age, sex, rurality, neighborhood income, cancer characteristics, chemotherapy exposure, comorbidities, previous healthcare use, influenza season, and calendar time of testing.

Results

We identified 24,668 cancer patients who underwent influenza testing, with 3991 (16%) testing positive and 10,929 (44%) vaccinated. Mean age was 70 years, 52% were male, mean time since cancer diagnosis was 6 years, 79% had a solid tumor malignancy, and 24% were receiving active chemotherapy. The overall adjusted VE (aVE) against laboratory-confirmed influenza was 21% (95%CI, 15%, 27%). The aVE among patients with a solid tumour malignancy was 25% (95%CI, 19%, 31%) as compared with –2% (95%CI, –20%, 14%) amongst patients with a hematologic malignancy (p-value for interaction <0.01). The aVE among patients receiving active chemotherapy was 9% (95%CI, –7%, 23%), compared with 23% (95%CI, 17%, 29%) among patients not on active chemotherapy (p-value for interaction=0.13).

Conclusions

Our results support recommendations for influenza vaccination among cancer patients and survivors. Influenza vaccination appears to be less effective among those undergoing active chemotherapy and we observed uncertain effectiveness among hematologic cancer patients. Strategies to improve VE and influenza vaccine uptake among cancer patients and their families are warranted.

Clinical trial identification

Legal entity responsible for the study

Phillip Blanchette and Jeff Kwong.

Funding

The study was funded by The Canadian Institute for Health Research and Ministry of Health and Long-Term Care in Ontario which provide funding support for Public Health Ontario (PHO) and The Institute of Clinical Evaluative Science (ICES).

Editorial Acknowledgement

Disclosure

K.I. Pritchard: Consultancy: Pfizer, Roche, Amgen, Novartis, Eisai, Genomic Health. A. McGeer: Research funding: Sanofi Pasteur, GlaxoSmithKline. All other authors have declared no conflicts of interest.

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