Abstract 2695
Background
Our hospital has about 650 beds. Since 2008, the multidisciplinary tumours team (MDT) evaluates once a week, all new cases of head and neck cancer, approximately 75/year. The main objective is to ascertain the 2-year survival of patients with squamous cell cancer of the head and neck (HNSCC) treated by a MDT and without an MDT, determining whether there are statistically significant differences.
Methods
Observational retrospective study of two cohorts, which aims to analyse the survival in the cohort by an MDT (C1, those from 01/01/2005 to 12/31/2008) with respect to the cohort without an MDT (C2, 01/01/2009 to 12/31/2012). We included all patients with an initial diagnosis of HNSCC at our centre. With access to the Pathological Anatomy database, the records of the MDT, the medical history, we collected the primary endpoint (survival at 2 years) and characteristics related to the patient, tumour, treatment and tracking (date and cause of death). Definitive sample consists of 408 patients, 200 in pre-MDT cohort and 208 in post-MDT cohort. A descriptive analysis is given of the demographic, clinical and epidemiological characteristics of the sample and a survival analysis with rates calculated using the Kaplan Meier method. The log-rank test was used to assess the differences in survival between cohorts, and a Cox proportional-hazards regression model was used to perform the univariate and multivariate survival analysis.
Results
Our population presents age (mean) 64.2y (SD 12.4), male 82.6%, ECOG<2 89%, 32.1% laryngeal location, tumour stage IVA 31.6%. Treatment with surgery (S) 43.4%. From our comparative analysis we want to highlight (C1 vs C2) 2-years OS was 59.5% and 70.2% (p = 0.042). After univariate and multivariate survival analysis, MDT is an independent variable of better prognosis in terms of overall survival in our study (HR 0.696).
Conclusions
The population served in our area presents demographic and clinical and epidemiological characteristics similar to those of other series published in our country. There is a statistically significant improvement in the survival of patients treated by MDT, this approach being an independent variable of better prognosis in terms of overall survival in our study.
Clinical trial identification
Legal entity responsible for the study
M. J. Martínez-Ortiz.
Funding
Has not received any funding.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.