Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

2304 - Impact of postoperative residual tumor and meningeal dissemination in adult medulloblastoma: a retrospective analysis.

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Topics

Surgical Oncology

Tumour Site

Central Nervous System Malignancies

Presenters

Rafael Barreto

Citation

Annals of Oncology (2018) 29 (suppl_8): viii122-viii132. 10.1093/annonc/mdy273

Authors

R. Barreto, P.A.H. Viveiros, M.C. Mesquita, V.M. Santos, O. Feher

Author affiliations

  • Oncologia Clínica, ICESP - Instituto do Câncer do Estado de São Paulo, 01426-030 - São Paulo/BR
More

Resources

Abstract 2304

Background

Medulloblastoma (MB) is the most common central nervous system (CNS) malignant tumor in children and reaches its peak in the first decade of life. In adults, MB is very rare, comprising less the 1% of total CNS tumors. Although molecular subtypes are well defined, the impact of other prognostic variables, such as postoperative residual tumor (PRT) and the presence of neuroaxis dissemination (NAD) are controversial.

Methods

We performed a retrospective analysis in consecutive adult patients with MB treated at Instituto do Câncer do Estado de São Paulo from 2008 to 2016. Patients data on tumor histology, ECOG-PS at diagnosis, low/high-risk clinical classification (according to tumor size, metastasis, NAD and PRT) and adjuvant radiotherapy (RT) or chemotherapy (CT) were reviewed through medical records.

Results

Thirty-eight patients were included. Median age was 28,8 years-old (18,3 to 40,8) and patients were followed-up for a median of 5,28 years. Five patients died during follow-up, all cancer related, and 8 had progression events. All patients were submitted to surgical resection; 15 were considered high-risk patients; 34 were submitted to RT and 23 to CT in addition to RT. The most common RT regimen was 36Gy on neuroaxis and 18Gy boost on the posterior fossa (67%) and the most common CT protocol was a combination of lomustine, vincristine and cisplatin (39%). The two most common histological subtypes were classical (19), followed by desmoplastic (14). Fifteen patients were considered high-risk. On univariate analysis, the presence of PRT (p < 0,0001) and NAD (p = 0,008) had a negative impact on survival. Cox proportional-hazards regression for multivariate analysis confirmed the detrimental impact of PRT, while NAD had a marginal effect.

Conclusions

Medulloblastoma seems to bear a general favorable prognosis among adults. The presence of postoperative residual tumor, and perhaps neuroaxis dissemination, seem to impact negatively survival.

Clinical trial identification

Legal entity responsible for the study

Olavo Feher.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.