Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Discussion session - CNS tumours

4302 - Impact of a molecular prescreening program (MPP) in the management of patients with non-glioblastoma brain tumors.


20 Oct 2018


Poster Discussion session - CNS tumours


Pathology/Molecular Biology

Tumour Site

Central Nervous System Malignancies


José Carlos Benítez Montañez


Annals of Oncology (2018) 29 (suppl_8): viii122-viii132. 10.1093/annonc/mdy273


J.C. Benítez Montañez1, M. Vieito Villar2, C. Hierro2, M. Gonzalez Rodriguez2, I. Matos2, I. Braña Garcia2, C. Suarez Rodriguez2, E.A. Martinez Saez3, M.C. Perez-Gago2, R. Morales-Barrera2, C. Ortiz2, C. Suarez2, X. Maldonado4, F. Martinez-Ricarte5, C. Auger6, A. Azaro2, R. Dienstmann7, J. Carles2, E. Garralda2

Author affiliations

  • 1 Medical Oncology, Hospital Mutua de Terrassa, 8221 - Terrassa/ES
  • 2 Oncology, Vall d`Hebron Institute of Oncology (VHIO)-Cellex Center, 08035 - Barcelona/ES
  • 3 Pathology, Vall d'Hebron University Hospital, 08035 - Barcelona/ES
  • 4 Radiation oncology, Vall d'Hebron University Hospital, 08035 - Barcelona/ES
  • 5 Neurosurgery, Vall d'Hebron University Hospital, 08035 - Barcelona/ES
  • 6 Radiology, Hospital Vall d'Hebron, 08035 - Barcelona/ES
  • 7 Oncology Data Science, Vall d'Hebron University Hospital, 08035 - Barcelona/ES


Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 4302


Although patients(pts) with low-grade gliomas and anaplastic tumors have better outcomes than those with glioblastoma, most pts that relapse will die as a consequence of their disease. There is an unmet clinical need for new treatments in this population.


Between 2014-2017, 145 pts with brain tumors were evaluated in the Early Drug Development Unit at Vall d´Hebron Institute of Oncology and included in our MPP. Clinical and molecular data from 36 pts (24%) with non-glioblastoma diagnosis were retrospectively reviewed.


Median age at diagnosis was 33 years. The majority were low-grade tumors (62.2%) with astrocytic differentiation (51.4%). Most pts (78.4%) were initially treated in other institutions (78%) with a median time since diagnosis to referral of 60.6 months (CI95%). Most pts (81%) were temozolomide-refractory. Molecular profiling identified a potentially targetable alteration in 78% of the cases. This included IDH mut (54%), PIK3CA/PTEN mut (16%), EGFR fusion (5%) and FGFR mutation/fusions (5%) and BRAF mutations/translocations(5%). Eleven cases (29%) were enrolled in phase 1 clinical trials and 4 (11%) in molecularly matched clinical trials (2 IDH inhibitor, 2 FGFR inhibitor). One patient with a IDH1132H mut treated with a IDH inhibitor achieved a stable disease >10 months and another with FGFR1 E17-TACC1 translocation has an ongoing partial response lasting over 6 months. Median overall survival (OS) since the referral to our unit was of 32 weeks (CI95%18 to 45), 78% survived at least 12 weeks and only 4 died during the first month(11,1%). Pts enrolled in matching trials had numerically better survival than those who entered unmatched trials (44 vs 22 weeks, p = 0,131).


Although rare, the high presence of drugable mutations and the lower likelihood of early death compared to glioblastoma makes them an interesting target for molecular prescreening and inclusion in phase I clinical trials.

Clinical trial identification

Legal entity responsible for the study

Vall d'Hebron Institute of Oncology (VHIO).


Has not received any funding.

Editorial Acknowledgement


J. Carles: Speaker bureau: Bayer, Janssen; Advisor committee: BMS, MSD, Janssen, Astellas, Pfizer. E. Garralda: Advisory role: Roche, NeoMed Therapeutics, Ellypses Pharma. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.