Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

5428 - Gastric Cancer In Young Patients

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Topics

Cancers in Adolescents and Young Adults (AYA)

Tumour Site

Gastric Cancer

Presenters

Mehmet Metin Seker

Citation

Annals of Oncology (2018) 29 (suppl_8): viii205-viii270. 10.1093/annonc/mdy282

Authors

M.M. Seker1, A. Bahceci2, T. Kacan2

Author affiliations

  • 1 Medical Oncology Department, Cumhuriyet University Faculty of Medicine, 58000 - Sivas/TR
  • 2 Medical Oncology Department, Cumhuriyet University Faculty of Medicine, Sivas/TR
More

Resources

Abstract 5428

Background

The majority of gastric cancer-related studies include elderly patients. Studies have shown that gastric cancer carries more poor prognostic factors in younger patients.

Methods

In this study we retrospectively reviewed the results of gastric cancer patients under age 30 who had diagnosed and treated at our hospital. Statistical analysis of the study was done by the Kaplan-Meier test, Long Rank test and Cox regression analysis in the SPSS17 statistical program.

Results

824 patients had diagnosed with gastric cancer at our clinic. Of these, 30 (3.6%) patients were under 30 years of age. 17 of them were women (56.6%) and 13 of them were men (43.4%). Of these, the results of 22 patients, 9 males and 13 females, whose data were available, had evaluated. At the time of diagnosis, 5 patients (23%) were stage 2, 6 patients (27%) were stage 3, and 11 patients (50%) had metastatic disease. R0 resection was performed in 10 patients (90.9%) and R2 resection was performed in 1 patient (9.1%). Palliative surgery had performed in 4 (36.3%) of 11 metastatic patients. The tumor was grade 1 in 5,5% of patients, grade 2 in 16,6%, grade 3 in 77,8%. The tumor was diffuse type in 83.3% of patients and intestinal type in 16.6% of patients. The median follow-up was 11 months (2-101 months). Median progression free survival (PFS) was 3 months in metastatic patients, but median PFS was not achieved in non-metastatic patients. The 1 year PFS was 58% (p = 0.001) in non-metastatic patients (Figure 1A). Median overall survival (OS) was 6 months in metastatic patients, and median OS was not achieved in non-metastatic patients (p = 0.001). The estimated OS was 67 months in non-metastatic patients (Figure 1B). Tumor grade, histopathological subtype, presence of lymphovascular and perineural invasion and chemotherapy regimens were not correlated with PFS and OS. There was no correlation between OS and serum CEA, AFP, Ca19-9 and Ca125 levels at the time of diagnosis.

Conclusions

The ratio of gastric cancer under age 30 varies between 1-2% in the literature. In our study, the ratio of patients under 30 years old was 3.6%. Although young patients have more poor prognostic criteria such as diffuse type, proximal location, high grade, and lymphovascular invasion, the survival rates were similar to the elderly patients, according to the other studies in the literature.

Clinical trial identification

Legal entity responsible for the study

Cumhuriyet University Faculty of Medicine.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.