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EONS Poster diplay

2345 - EONS Poster - Effect of Aromatherapy Massage on Chemotherapy-Induced Peripheral Neuropathic Pain and Fatigue in Patients Receiving Oxaliplatin


22 Oct 2018


EONS Poster diplay


Management of Systemic Therapy Toxicities;  Supportive Care and Symptom Management

Tumour Site


Nur Izgu


Annals of Oncology (2018) 29 (suppl_8): viii698-viii701. 10.1093/annonc/mdy278


N. Izgu1, L. Ozdemir2, F. Bugdayci Basal3

Author affiliations

  • 1 Nursing Faculty, Hacettepe University, 06100 - Ankara/TR
  • 2 Nursing Faculty, Hacettepe University, 06000 - Ankara/TR
  • 3 Medical Oncology, Ataturk Chest Diseases and Surgery Training and Research Hospital, Ankara/TR


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Abstract 2345


Patients receiving oxaliplatin may experience peripheral neuropathic pain and fatigue. Aromatherapy massage, a nonpharmacological method, may help to control these symptoms.


The aim of this open-label, parallel-group, quasi-randomized controlled pilot study was to investigate the effect of aromatherapy massage on chemotherapy-induced peripheral neuropathic pain and fatigue in patients receiving oxaliplatin. Stratified randomization was used to allocate 46 patients to 2 groups: intervention (n = 22) and control (n = 24). Between week 1 and week 6, participants in the intervention group (IG) received aromatherapy massage 3 times a week. There was no intervention in weeks 7 and 8. The control group (CG) received routine care. Neuropathic pain was identified using the Douleur Neuropathique 4 Questions; severity of painful paresthesia was assessed with the numerical rating scale; fatigue severity was identified with the Piper Fatigue Scale.


At week 6, the rate of neuropathic pain was significantly lower in the IG, when compared with the CG. The severity of painful paresthesia based on numerical rating scale in the IG was significantly lower than that in the CG at weeks 2, 4, and 6. At week 8, fatigue severity in the IG was significantly lower when compared with CG (P < .05).


Aromatherapy massage may be useful in the management of chemotherapy-induced peripheral neuropathic pain and fatigue. This pilot study suggests that aromatherapy massage may be useful to relieve neuropathic pain and fatigue. However, there is a need for further clinical trials to validate the results of this study.

Clinical trial identification

Legal entity responsible for the study

Hacettepe University.


Hacettepe University Scientific Research Projects Coordination Unit.

Editorial Acknowledgement


All authors have declared no conflicts of interest.

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