Skin reactions during radiotherapy (RT) are common in women with breast cancer (BC). Different methods have been tested to reduce or prevent this toxicity. The aim of this study was to explore if genetic variation can be linked to acute radiation skin reactions (ARSR).
One hundred and nineteen women undergoing RT for BC during the period of 2011 to 2013 were included. Symptoms such as itching, burning and irritation were self-reported twice (during the first and last week of RT) using the VAS-scale. Assessments of the irradiated skin were measured using the Radiation Therapy Oncology Group scoring system for acute RT (RTOG-scale). Blood-based SNP analysis were performed using peripheral blood sample (obtained before start of RT). In total, 29 SNPs of well-defined functional genes were investigated.
All women were assessed with ARSR in various degree according to the RTOG-scale. During the last week of RT, the women self-reported itching (n = 97, 82 %), burning (n = 64, 54 %) and irritation (n = 96, 81 %.). Three SNPs in the following genes were found to be associated with ARSR: XRCC2, IFNg and CCL5/Rantes.
We found an association between three SNPs and ARSR. The possibility of using these SNPs as prognostic biomarkers for radiation-induced toxicity needs further investigation.
Clinical trial identification
Legal entity responsible for the study
County Hospital Ryhov, Jönköping Sweden.
This investigation was partly supported by Foundation for Clinical Cancer Research in Jönköping and Futurum Academy for Health and Care, Region Jönköping County, Sweden and FORSS - Medical Research Council of Southeast Sweden.
All authors have declared no conflicts of interest.