Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Discussion session - Supportive and palliative care 1

1312 - Effects of 6-month exercise training on quality of life in pancreatic cancer patients: results from a randomized controlled trial


20 Oct 2018


Poster Discussion session - Supportive and palliative care 1


Supportive Care and Symptom Management

Tumour Site

Pancreatic Adenocarcinoma


Karen Steindorf


Annals of Oncology (2018) 29 (suppl_8): viii603-viii640. 10.1093/annonc/mdy300


K. Steindorf1, D. Clauss1, C. Tjaden2, F. Herbolsheimer1, L. Schneider2, C. Ulrich3, T. Hackert2, J. Wiskemann4

Author affiliations

  • 1 Division Of Physical Activity, Prevention And Cancer, German Cancer Research Center, 69120 - Heidelberg/DE
  • 2 Department Of General Surgery, University Hospital Heidelberg, 69120 - Heidelberg/DE
  • 3 Department Of Population Health Sciences, Huntsman Cancer Institute, 84112 - Salt Lake City/US
  • 4 Medical Oncology, Nationales Zentrum für Tumorerkrankungen (NCT), 69120 - Heidelberg/DE


Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 1312


Given the poor prognosis and high symptom burden of pancreatic cancer, preservation of quality of life (QoL), physical functioning and minimization of adverse treatment effects are important treatment goals in pancreatic cancer patients. Even though exercise has proven to provide health benefits, including improvements in QoL, in patients with various cancer types, studies are rare for more aggressive cancer types like pancreatic cancer. Therefore, we conducted a randomized controlled trial to assess the efficacy of a 6-month resistance training (RT) on QoL in pancreatic cancer patients.


Sixty-five pancreatic cancer patients, mostly stage IIb after tumor resection and during chemotherapy, were assigned to one of two progressive RT groups (supervised or home-based) or to usual care for 6 months. The primary outcome, the physical functioning subscale of the EORTC QLQ-C30, and other QoL-related outcomes were assessed before the intervention, after 3 and 6 months.


Forty-seven patients (mean age: 60.5 years, 53.2% males) completed the intervention period. After 6 months, no between-group differences were observed. However, after 3 months, intention-to-treat analyses showed significant between-group mean differences (MD) in favor for the pooled RT group for physical functioning (MD = 12.0; p = 0.010), as well as for overall QoL (MD = 12.5; p = 0.014), and several other secondary outcomes (cognitive functioning, insomnia, physical fatigue, and reduced activity). Both modes of delivery, supervised and home-based resistance-training, showed similar effects. Overall mean training adherence rate was 66.5%, with a steady decrease over the 6-month intervention period.


This was the first randomized controlled RT intervention trial in pancreatic cancer patients. The findings showed clinically relevant improvements in QoL after 3 but not 6 months. Given the severity of pancreatic cancer and the importance of maintaining QoL, patients should be timely advised to perform exercise. Future research needs to focus on prolonging the positive mid-term effects, possibly through improving training adherence.

Clinical trial identification


Legal entity responsible for the study

German Cancer Research Center.


German Cancer Aid (Foundation).

Editorial Acknowledgement


All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.