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Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

2014 - Computed tomography features of resected lung adenocarcinomas with spread through air spaces

Date

20 Oct 2018

Session

Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

Topics

Staging and Imaging

Tumour Site

Presenters

Yuichi Yamada

Citation

Annals of Oncology (2018) 29 (suppl_8): viii641-viii644. 10.1093/annonc/mdy301

Authors

Y. Yamada1, G. Toyokawa2, T. Tagawa3, T. Kamitani4, Y. Yamasaki4, F. Shoji2, K. Yamazaki2, S. Takeo2, Y. Oda1

Author affiliations

  • 1 Department Of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 812-8582 - Fukuoka/JP
  • 2 Department Of Thoracic Surgery, National Hospital Organization, Kyushu Medical Center, 810-8563 - Fukuoka/JP
  • 3 Department Of Surgery And Science, Graduate School of Medical Sciences, Kyushu University, 812-8582 - Fukuoka/JP
  • 4 Department Of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 812-8582 - Fukuoka/JP
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Resources

Abstract 2014

Background

Spread through air spaces (STAS) is a recently-recognized invasive pattern of lung cancer defined as ‘micropapillary clusters, solid nests or single cells beyond the edge of the tumor into air spaces.’ Since STAS has been shown to be a significant prognosticator for the postoperative survival, predicting STAS preoperatively by computed tomography (CT) might help determine the optimum surgical procedures.

Methods

Information on STAS and preoperative CT were availablen 327 patients with resected lung adenocarcinomas. STAS was defined as tumor cells within air spaces in the lung parenchyma beyond the edge of the main tumor. The association of STAS with CT characteristics, such as vascular convergence, ground glass opacity (GGO), air bronchogram, notch, pleural indentation, spiculation, and cavitation, was analyzed.

Results

Among the 327 patients with resected adenocarcinoma, 191 (58.4%) were positive for STAS. A univariable analysis demonstrated that STAS-positive adenocarcinomas were significantly associated with a larger radiological tumor diameter (P = 0.02), the presence of vascular convergence (P < 0.01), notch (P < 0.01), pleural indentation (P = 0.03), spiculation (P < 0.01), and the absence of GGO (P < 0.01) compared with STAS-negative ones. In a multivariable analysis, the presence of notch (P = 0.01) and the absence of GGO (P < 0.01) were shown to be significantly associated with the STAS phenomenon. The odds ratio for STAS of notch-positive and GGO-negative adenocarcinomas against notch-negative and GGO-positive ones was 5.01 (P < 0.01).

Conclusions

The presence of notch and the absence of GGO were independently associated with the STAS phenomenon. These results will prove helpful in identifying STAS-positive adenocarcinoma by CT prior to surgical resection.

Clinical trial identification

Legal entity responsible for the study

Gouji Toyokawa.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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