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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

3422 - Clinical Characteristics of 3,030 Glioblastoma Multiforme (GBM) Patients in High, Upper Middle and Lower Middle Economic Regions Based on Real-World Data (RWD)

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Topics

Bioethical Principles and GCP

Tumour Site

Central Nervous System Malignancies

Presenters

Laura Mitrofan

Citation

Annals of Oncology (2018) 29 (suppl_8): viii122-viii132. 10.1093/annonc/mdy273

Authors

L.M. Mitrofan1, M.R. Krukas-Hampel2, L.A. Mendoza3

Author affiliations

  • 1 Real World Evidence Solutions, Oncology, IQVIA, 92099 - Paris/FR
  • 2 Consulting Services, IQVIA Global Consulting Services, 485 - New York/US
  • 3 Medical Strategy & Science, Oncology-hematology, IQVIA, 15800 - Prague/CZ
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Resources

Abstract 3422

Background

GBM is the most common and aggressive primary brain tumor in adults. This study investigated RWD-based differences among 3,030 GBM patients stratified by three economic regions.

Methods

The analysis was based on IQVIA syndicated cross-sectional surveys, collecting anonymized patient-level data between January 2016 and September 2017 in different countries, grouped into three economically different regions. Region 1 (high): EU5 (France, Germany, Italy, UK, Spain), Canada, Australia; Region 2 (upper middle): Korea, China, Taiwan; Region 3 (lower middle): Brazil, Mexico.

Results

The percentage of patients aged >65 years was 23.9 % for region 1, 6.33 % for region 2 and 13.62 % for region 3, confirming younger GBM population in region 2. The age difference among the regions was statistically significant (P < 0.0001). The incidence of male (65 %) and female (35 %) patients was homogenous across all regions. Region 1 showed the highest testing rate (60 %) for MGMT promoter methylation and region 3 the lowest (33 %). EGFR mutation was not studied in more than 50 % of patients across the regions. However, in overall tested population, the EGFR VIII mutations varied: 39 %, 90 %, and 73 % for regions 1, 2 and 3, respectively. Concerning drug treatment options, temozolomide was the leading therapy (> 90 %) in all three regions, regardless of MGMT and EGFR status. The highest percentage (35 %) for cognitive impairment studied by MMSE (Mini Mental State Examination) was found in region 2, followed by 25 % and 22 % in regions 1 and 3, respectively. We did not find any differences in Performance Status or comorbidities among the regions, with no reported comorbidities in > 60 % of patients.

Conclusions

This multi-variable analysis from RWD shows differences in clinical characteristics (i.e., age, biomarkers and MMSE), which may be taken into consideration in the design of GBM global studies. To our best knowledge, this study was based on the largest GBM database ever published.

Clinical trial identification

Legal entity responsible for the study

IQVIA.

Funding

IQVIA.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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