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Poster Discussion session - Developmental therapeutics / investigational immunotherapy

3099 - Clinical activity, safety, and PK/PD from a Phase 1 study of RO6874281, a fibroblast activation protein (FAP) targeted interleukin-2 variant (IL-2v)

Date

20 Oct 2018

Session

Poster Discussion session - Developmental therapeutics / investigational immunotherapy

Topics

Clinical Research;  Cytotoxic Therapy

Tumour Site

Presenters

Ignacio Melero

Citation

Annals of Oncology (2018) 29 (suppl_8): viii133-viii148. 10.1093/annonc/mdy279

Authors

I. Melero1, E. Castanon Alvarez2, M. Mau-Sorensen3, U.N. Lassen4, M.P. Lolkema5, D.G. Robbrecht6, C.A. Gomez-Roca7, J. Martin-Liberal8, J. Tabernero9, W. Ros10, S. Ahmed11, N. Isambert12, H. Piper Lepoutre13, C. Boetsch14, J. Charo15, S. Evers16, V. Teichgräber15, J.H.M. Schellens17

Author affiliations

  • 1 Laboratory Of Immunology, Clinica Universitaria de Navarra, 31008 - Pamplona/ES
  • 2 Medical Oncology, Clinica Universitaria de Navarra, 31008 - Pamplona/ES
  • 3 -, SKACCD - Rigshospitalet, 2100 - Copenhagen/DK
  • 4 Finsen Center, Dept. Of Oncology, Phase 1 Unit, Copenhagen University Hospital - Rigshospitalet, 2100 - Copenhagen/DK
  • 5 Medical Oncology, Erasmus University Medical Center, 3015 CE - Rotterdam/NL
  • 6 Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, 3075 EA - Rotterdam/NL
  • 7 Medical Oncology & Clinical research, Institut Universitaire du Cancer -Toulouse- Oncopole, 31059 - Toulouse/FR
  • 8 Oncology, Vall d`Hebron Institute of Oncology (VHIO)-Cellex Center, 08035 - Barcelona/ES
  • 9 Medical Oncology, Vall d'Hebron University Hospital, 08035 - Barcelona/ES
  • 10 Medical Oncology, Netherlands Cancer Institute, Amsterdam/NL
  • 11 Leicester Cancer Research Centre, University Hospitals of Leicester NHS Trust Leicester Royal Infirmary, LE1 5WW - Leicester/GB
  • 12 Medical Oncology, Centre Georges-François Leclerc (Dijon), 21079 - Dijon/FR
  • 13 Safety Sciences, Roche Innovation Center Basel, 4070 - Basel/CH
  • 14 Pharmaceutical Sciences, Roche Innovation Center Basel, 4001 - Basel/CH
  • 15 Translational Medicine Oncology, Roche Innovation Center Zurich, 8952 - Schlieren/CH
  • 16 Oncology Dta, Roche Innovation Center Basel, 4001 - Basel/CH
  • 17 Division Of Clinical Pharmacology, Department Of Medical Oncology, The Netherlands Cancer Institute, Amsterdam/NL
More

Resources

Abstract 3099

Background

High-dose IL-2 is approved for patients with metastatic melanoma and renal cell carcinoma but is associated with significant toxicity, frequently requiring intensive care. RO6874281 carries an engineered IL2v moiety with abolished binding to IL-2Ra. Affinity to IL-2Rβγ is retained, resulting in activation of immune effector CD8 T and NK lymphocytes, but reduced activity on regulatory T cells (Tregs). The antibody part of RO6874281 binds with high affinity to FAP, which is strongly expressed on tumor-associated fibroblasts, and mediates retention and accumulation in malignant lesions.

Methods

Study BP29842 investigates safety, PK/PD and anti-tumor activity of RO6874281, administered i.v. once per week in an outpatient setting to patients with metastatic solid tumors. The dose escalation part enrolled 28 patients with metastatic solid tumors and identified a recommended dose (RD) of 20mg, using one-step intra-patient escalation (15mg followed by 20mg). Patients with treatment refractory melanoma and squamous cell carcinomas are enrolled to an extension cohort to confirm safety and further explore PK/PD and activity of the RD. So far, 16 patients were enrolled to this cohort including 6 with melanoma.

Results

To date, most frequent adverse events (>30%) were pyrexia, infusion related reactions, fatigue/asthenia, nausea, diarrhea, decreased appetite and elevated aspartate and/or alanine transaminase. The majority of events were mild or moderate (Grade 1/ 2). At RD, RO6874281 rapidly expands CD8 and NK cells but not Tregs, both in peripheral blood and sequential tumor biopsies. Objective long-lasting (> 6 months) responses were observed in one patient each with head and neck cancer, penile squamous cell carcinoma and checkpoint inhibitor resistant malignant melanoma across the escalation dose range. Further, tumor shrinkage was observed in 4 melanoma patients, including 1 uveal and 1 mucosal.

Conclusions

RO6874281 is the first targeted IL-2 variant with acceptable outpatient safety to display monotherapy activity, including in tumor types not previously reported to respond to IL-2. Ph1b/Ph2 studies in combination with atezolizumab and other agents are currently underway.

Clinical trial identification

NCT02627274; EudraCT: 2015-002251-97, first posted: December 10, 2015.

Legal entity responsible for the study

F. Hoffmann-La Roche Ltd.

Funding

F. Hoffmann-La Roche Ltd.

Editorial Acknowledgement

Disclosure

H. Piper Lepoutre, C. Boetsch, J. Charo, S. Evers, V. Teichgräber: Employee with stock options: F. Hoffmann-La Roche Ltd. All other authors have declared no conflicts of interest.

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