Abstract 2376
Background
Carcinosarcomas are rare tumors that comprise microscopic features of both epithelial tumors (carcinomas) and connective tissue tumors (sarcomas). Data about carcinosarcoma are relatively scarce. In this study, data about carcinosarcoma in the SEER’s database were explored and further analyzed and summarized. SEER incorporates clinical and epidemiological data from 18 cancer registries all over the United States and presented data can be extrapolated to generate evidence on this rarely occurring tumor.
Methods
SEER*Stat Version 8.3.5 was used to obtain data from the SEER 18 Regs Nov 2017 Submission database. Cases diagnosed between 2000-2015 with carcinosarcoma (ICD-O-3 8980/3, 8981/3) were included. Both SEER*Stat and SPSS were used for further data analysis.
Results
A total of 8365 patients were diagnosed with carcinosarcoma between 2000 and 2015, with a median age of 68. The disease occurred predominantly in females (n = 7578; 90.6%) and was more common in white race (n = 6231; 74.5%). Incidence rate was 6.2 per million (CI: 6.1-6.3) with a significant increase of incidence over time (annual percent change = 6.1%) The most common sites for occurrence were the corpus uteri (n = 4656; 55.7%) and ovary (n = 1100; 13.2%) followed by other part of the female genital system (n = 886; 10.6%). The disease was the only primary tumor in 5969 (71.4%) of cases, and the first of 2 or more primaries in 493 patients (8.3%). It occurred as a second or later multiple primary in the remaining percentage of patients (n = 1903; 22.7%). Median survival was 20.5 months, with 5-years and 10-years observed survival being 30.6% (CI: 29.3-31.9%) and 22.4% (CI: 21-23.8%) respectively. Relative survival at 5 years and 10 years was 34.5% (CI: 33.1-36%) and 29.5% (CI: 27.7-31.3%) respectively.
Conclusions
Carcinosarcoma is a rare tumor that occurs with an incidence rate of 6.2 per million. It is predominantly a disease of females who represents 90.6% of cases with female genital system being the main site of occurrence. The disease occurred as a second (or later) primary in 22.7% of patients. It has a median survival of 20.5 months and a relative 5-years survival of 34.5%.
Clinical trial identification
Legal entity responsible for the study
Mohamed Alaa Gouda.
Funding
Has not received any funding.
Editorial Acknowledgement
Disclosure
The author has declared no conflicts of interest.
Resources from the same session
4942 - Analytical validation of OncoMasTR, a multigene test for predicting risk of distant recurrence in hormone receptor-positive early stage breast cancer
Presenter: Tony Loughman
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
5641 - Comparing the prognosis of favourable-histology breast cancers between younger women of less than 45 years of age at diagnosis with their older counterparts.
Presenter: Guek Eng Lee
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4448 - TNBC universe: a monocentric retrospective analyses of TILs and AR as prognostic markers
Presenter: Agnese Losurdo
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4755 - Genomic spectrum of Asian breast cancer based on targeted next-generation sequencing in 150 consecutive primary breast cancer
Presenter: Chihwan Cha
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
2741 - The Impact of the 21 Gene Recurrence Score (RS) on Chemotherapy (CHemoRx) Prescribing in Hormone Receptor (HR) Positive, Lymph Node Positive (LN+) Early-Stage Breast Cancer (BC) in Ireland: A National, Multi-centre, Prospective Study (CTRIAL-IE 15-34)
Presenter: Anees Hassan
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
3356 - Lymphocyte-predominant breast cancer has a significant lower mean of absolute neutrophil counts compared to non-lymphocyte-predominant breast cancer: Analyses with 576 cases
Presenter: Da Young Lee
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4020 - Genetic Alterations of Early-Stage Breast Cancers by next-generation sequencing (NGS)
Presenter: Yan Xu
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4924 - Oncotype Dx results in patients _40 years, Does age matters?: new insights
Presenter: Fernando Namuche
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
2646 - Impact of BRCA status on outcomes and survival in high-risk early breast cancers
Presenter: Elodie Klajer
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4516 - Early breast cancer classified as intermediate risk by the Prosigna assay: Characteristics and treatment strategy
Presenter: Nawale Hajjaji
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract