Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

2125 - Brain metastases in primary ovarian cancer: real-world data

Date

20 Oct 2018

Session

Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research

Topics

Supportive Care and Symptom Management

Tumour Site

Ovarian Cancer

Presenters

Elena Ratner

Citation

Annals of Oncology (2018) 29 (suppl_8): viii332-viii358. 10.1093/annonc/mdy285

Authors

E. Ratner1, M. Bala2, M. Louie-Gao2, S. Hazard3, P. Brastianos4

Author affiliations

  • 1 Obstetrics, Gynecology And Reproductive Sciences, Yale University, 06511 - New Haven/US
  • 2 Health Economics And Outcomes Research, TESARO, Inc., Waltham/US
  • 3 Clinical Science, TESARO, Inc., Waltham/US
  • 4 Hematology/oncology, Dana-Farber Harvard Cancer Center, Harvard Medical School, Hematology/Oncology, Massachusetts General Hospital, Boston/US
More

Resources

Abstract 2125

Background

Brain metastasis (BM) is infrequently reported in patients (pts) with ovarian cancer (OC), with past studies reporting a rate of approximately 1%.1 This study estimated real-world incidence of BM in OC and assessed whether BRCA mutation (BRCAmut) increased risk of BM in OC pts.

Methods

This retrospective study included 4515 pts diagnosed with OC between Jan 1, 2011 and Jan 31, 2018 from the Flatiron Health database. This is a longitudinal, demographically and geographically diverse database derived from electronic health record data from over 265 cancer clinics and over 2 million active US cancer pts. A time-to-event analysis was conducted to assess whether pts with a known BRCAmut were more likely to develop BM compared with BRCA wild type (BRCAwt) pts.

Results

Of 4515 OC pts, 473 were BRCAmut, 1679 were BRCAwt, and 2363 had unknown BRCA status. A total of 46 pts (1%) had a diagnosis of BM subsequent to OC diagnosis. Of those with BRCAmut, 3% (14/473) developed BM; the BM rate was 0.6% (10/1679) for BRCAwt. The K-M estimate for the proportion of pts with BM within 5 years of diagnosis was 5.7% in the BRCAmut population compared with 1.4% in BRCAwt. BRCAmut pts had a significantly higher risk of developing BM compared with BRCAwt (HR 4.44 [95% CI 1.97, 10.00], P < 0.0001). A total of 281 OC pts also had a breast cancer (BC) diagnosis (186 developed BC prior to OC, 95 developed BC after OC diagnosis). After excluding these pts from the analysis, the HR for developing BM among BRCAmut pts vs. BRCAwt pts was 3.84 (95% CI 1.60, 9.22), P = 0.001. Multivariate models adjusting for other pt characteristics yielded similar HRs. Among pts who developed BM, median time from OC diagnosis to BM diagnosis was 27 months in BRCAmut pts and 35 months in BRCAwt. Median survival after diagnosis of BM was 7.16 months (95% CI 3.48, 16.49). Overall survival after BM did not differ significantly by BRCA status.

Conclusions

OC pts with BRCAmut seem to have a higher risk of developing BM. Further research is needed to confirm these findings and better understand potential mechanisms and implications for management, given the poor prognosis in pts who develop BM. 1Pectasides et al. The Oncologist 2006;11:252–260.

Clinical trial identification

Legal entity responsible for the study

Tesaro, Inc.

Funding

Tesaro, Inc.

Editorial Acknowledgement

Editorial support, funded by Tesaro, Inc. (Waltham, MA, USA) and coordinated by Michael Stillman PhD of Tesaro, Inc., was provided by Dena McWain of Ashfield Healthcare Communications (Middletown, CT, USA).

Disclosure

E. Ratner: Advisory board: Tesaro Inc. M. Bala, M. Louie-Gao, S. Hazard: Employment and stock and other ownership interests in Tesaro Inc. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.