Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

4142 - Baseline Predictive Factors for efficacy of AntiPD1 used in first line in Melanoma Patients: an Italian Melanoma Intergroup study


21 Oct 2018


Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology



Tumour Site



Riccardo Marconcini


Annals of Oncology (2018) 29 (suppl_8): viii442-viii466. 10.1093/annonc/mdy289


R. Marconcini1, E. Tanda2, L.A. Di Guardo3, O. Nigro4, P. Fava5, A. Todisco6, F. Morgese7, A. Cortellini8, E. Stroppa9, G. Gallizzi10, L. Festino11, E. Grego12, S. Quadrini13, C. Orlandini1, A. Nuzzo1, S. Manacorda1, F. Bloise1, A. Indini3, C. Astrua5, A. Falcone1

Author affiliations

  • 1 Department Of Translational Research And New Technologies In Medicine And Surgery, University Of Pisa,, Unit of medical oncology, Azienda ospedaliero Universitaria Pisana, 56100 - Pisa/IT
  • 2 Department Of Medical Oncology, IRCCS AOU San Martino-Istituto Nazionale per la Ricerca sul Cancro,, Genova/IT
  • 3 S.s. Oncologia Medica Melanomi,, Fondazione IRCCS - Istituto Nazionale dei Tumori, 20133 - Milan/IT
  • 4 U.o. Oncologia Medica,, ASST-Settelaghi, Ospedale di Circolo di Varese,, Varese/IT
  • 5 Sc Dermatologia U., AOU Città della salute e della Scienza, Torino/IT
  • 6 Medical Oncology Unit, Department Of Biomedical Sciences And Clinical Oncology,, University of Bari, Bari/IT
  • 7 Clinica Oncologica Università Politecnica Delle Marche,, Azienda Ospedaliero-Universitaria Umberto I, ancona/IT
  • 8 Medical Oncology, Ospedale Civile San Salvatore, 67100 - L'Aquila/IT
  • 9 U.o. Oncologia Medica,, Ospedale "Guglielmo de Saliceto",, Piacenza/IT
  • 10 Sc Oncologia,, Ospedale SS Antonio e Biagio e C. Arrigo,, Alessandria/IT
  • 11 Melanoma Cancer Immunotherapy And Innovative Therapy Unit,, AOU Policlinico Federico II, 80131 - Napoli/IT
  • 12 U.o Oncologia Medica, Struttura Ospedaliera S. Chiara,, Trento/IT
  • 13 Oncologia Medica, Ospedale "Fabrizio Spaziani", 03039 - Sora/IT


Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 4142


AntiPD1 Nivolumab (N) or Pembrolizumab (P) are an option for first line treatment in metastatic melanoma (MM) but predictive factors of efficacy are needed to choose between them or other treatment (antiPd1+AntiCTLA4, BRAF+MEK inhibitors (BMEi) for BRAF mutated melanoma). Many studies suggest that LDH, ECOG PS, tumor burden can identify BRAF mutated MM patients (pt) in which BMEi show better outcome. Similar data are not available for N or P in first line. We evaluate pt treated with N or P in first line in order to verify if these factors or other factors can be applyed also to antiPD1.


A retrospective multicenter study was conducted in 13 Italian Oncology Centers, evaluating MM pt treated with N or P in first line from 2016. Endpoints were OS and PFS, Kaplan Mayer and Cox regression were applied for survival analysis.


236 pt were analyzed (51% treated with N, 7% BRAF mutated). ECOG PS was 0 in 169 pt, number of metastatic sites (Nu) was less then 3 in 135 pt, in 88 pt there were not visceral metastasis (Vi), LDH was normal in 141 pt, ratio between baseline neutrophils and total leukocytes count (Fr) was less then 0.7 in 152 pt: in univariate analysis, all this factors resulted significantly associated with better OS (all p < 0.0003) and PFS (all p < 0.003), the only exeption were pt with Nu less then 3 that resulted not signficantly different in PFS then pt with higher Nu (p 0.13). In multivariate analysis all these factors were confirmed as significantly associated with better PFS and OS (all p < 0.03), with the exeption of Nu (p 0.22) A score was counted for every pt considering the number of favorable baseline factors present (normal LDH, ECOG PS 0, Vi 0, Fr < 0.7) 18 months-PFS was 69% in pt with all 4 favorable factors vs 41% in pt without favorables factors (p value 0.0029). 18 months-OS was 90% in pt with all four favoreble factors vs 48% in pt without favorables factors (p value<0.0001).


ECOG PS 0, normal LDH, Fr < 0.7, absent Vi are indipendent baseline factors associated with favorable PFS and OS of MM pt treated with N or P in first line (instead of Nu – that was found relevant for BMEi in other study). Subgroup with all these factors has a better prognosis. These data can help first line treatment choice and should be evaluated prospectively.

Clinical trial identification

Legal entity responsible for the study

Italian Melanoma Intergroup I.M.I.


Has not received any funding.

Editorial Acknowledgement


R. Marconcini: Consultancy, Advisory board, Honoraria for speaking: BMS, MSD, Novartis, Roche. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.