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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

3163 - Association of Systemic and Local Inflammation with Prognosis in Rectal Cancer Treated with Neoadjuvant Radiotherapy

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Topics

Tumour Immunology

Tumour Site

Colon and Rectal Cancer

Presenters

Jinluan Li

Citation

Annals of Oncology (2018) 29 (suppl_8): viii150-viii204. 10.1093/annonc/mdy281

Authors

J. Li1, X. Zhang2, Y. Huang2, L. Tang2, Q. Peng2, J. Wu1

Author affiliations

  • 1 Department Of Radiation oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, 350014 - Fuzhou,Fujian/CN
  • 2 Department Of Radiation oncology, Fujian Medical University Cancer Hospital, 350014 - Fuzhou,Fujian/CN
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Resources

Abstract 3163

Background

To explore the characteristics of cancer-associated systemic and local inflammation and its impact on overall survival (OS) in locally advanced rectal cancer (LARC) treated with neoadjuvant radiotherapy (RT).

Methods

A consecutive cohort of 76 LARC patients underwent neoadjuvant RT were retrospectively analyzed from February 2012 to September 2015. Peripheral neutrophil to lymphocyte ratio (NLR) was calculated at diagnosis, and tumor-infiltrating lymphocyte was examined in postoperative tumor tissue by immunohistochemistry. The association between clinicopathological features and inflammation was explored through chi-square test. The prognostic factors in terms of OS were investigated through uni- and multivariate Cox regression. SPSS 22.0 was used for statistical analyses.

Results

The median follow-up time was 29.0 months (range, 2-59). The 1-, 3- and 5-year OS rates were 93.4% (95%CI 87.91-98.89), 80.0% (95%CI 69.81-90.19) and 68.6% (95%CI 46.06-91.14), respectively. High NLR (≥2.0) and low CD8+ T-cells (<9%) were more common in 76 patients (53.9% and 59.2%, respectively). For patients with high NLR and low CD8+ T-cells, 5-year OS was significantly worse than those with low NLR and high CD8+ T-cells (P = 0.005). Also, NLR ≥ 2.0 was associated with poor tumor regression after neoadjuvant RT (P = 0.039), while no significant association was found between CD8+ T-cells and tumor regression. In addition, NLR was related to lymphovascular invasion (P = 0.031). CD8+ T-cell was related to neural invasion (P = 0.048) and mucinous adenocarcinoma (P = 0.045). Furthermore, NLR (HR 7.71, 95%CI 1.30-45.71, P = 0.025), CD8+ T-cells (HR 0.09, 95%CI 0.01-0.67, P = 0.018) , age (HR 16.1, 95%CI 1.56-167.15, P = 0.020), lymphovascular invasion (HR 7.17, 95%CI 1.12-46.05, P = 0.038) and T stage (HR 0.03, 95%CI 0.00-0.45, P = 0.011) were independent risk factors for prognosis according to multivariate Cox regression.

Conclusions

High NLR and low CD8+ T-cells were significantly associated with dismal survival. Systemic combined with local inflammation might help to predict prognosis of LARC with neoadjuvant RT.

Clinical trial identification

Legal entity responsible for the study

Jun-xin Wu.

Funding

National Clinical Key Specialty Construction Program.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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