Abstract 5924
Background
At the same level of thrombocytopenia, patients with acute lymphoblastic leukemia (ALL), receive more prophylactic platelet transfusion in comparison to immune thrombocytopenia (ITP). Routine investigation cann’t differentiate the risk of bleeding between ALL and ITP. Sonoclot is a global test of coagulation, a bed side tool, also assesses platelet function. It is widely used in cardiac surgery and hepatology to assess need for blood plasma and platelet transfusion. Aim of the study was to evaluate role of sonoclot in assessing the risk of bleeding in ALL with severe thrombocytopenia.
Methods
In this prospective observational study, twenty-five cases of ALL and fifty cases of ITP (control) were included. All patients included had platelet counts lower than 20000/μL and there was no evidence of any active bleeding. Blood samples were evaluated by conventional coagulation tests as well as by Sonoclot. Sonoclot measures activated clotting time (ACT), clot rate (R1) and platelet function (PF).
Results
Table: 1041P
Comparison of ALL and Control (ITP)
| ITP (n = 50) | ALL (n = 25) | |||
|---|---|---|---|---|
| Parameters | (mean ± SD) | (mean ± SD) | p | Normal Value |
| Platelet (/μL) | 9536.73 ± 5048.05 | 12240 ± 4576.02 | NS | 150000-450000 |
| Prothombin time (seonds) | 14.1 ± 1.43 | 14.72 ± 2.13 | NS | 11-14 |
| Activated partial thromboplastin time (seconds) | 29.66 ± 1.99 | 29.77 ± 2.13 | NS | 25-35 |
| ACT (seconds) | 251.1 ± 37.97 | 260.16 ± 51.2 | NS | 100-155 |
| CR (unit) | 22.17 ± 6.43 | 19.56 ± 4.55 | 0.371 | 9-35 |
| PF (unit) | 1.54 ± 0.72 | 0.94 ± .83 | 0.007 | >1.6 |
Both the groups were matched for platelet count. There was no statistically significant difference between two groups when prothrombin time and activated partial thromboplastin time were compared. On sonoclot analysis, the ACT did not show any difference in the two groups, and though clot rate (CR) was different in two groups, it was not statistically significant. However, platelet function (PF) was significantly lower in the ALL than the ITP group (Table).
Conclusions
This is the first study to the best of our knowledge demonstrating the use of sonoclot in ALL with severe thrombocytopenia. We conclude that sonoclot, a point of care device, can assess the risk of bleeding amongst patients with ALL.
Clinical trial identification
Legal entity responsible for the study
Kundan Mishra.
Funding
Has not received any funding.
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
5877 - TCR beta chain convergence defines the tumor infiltrating T cell repertoire of melanoma and non-small cell lung carcinoma.
Presenter: Timothy Looney
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
3212 - PI3K inhibition and modulation of immune and tumor microenvironment markers by copanlisib in patients with non-Hodgkin's lymphoma or advanced solid tumors
Presenter: Ahmad Awada
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
3574 - Pan-squamous genomic profiling stratified by anatomic tumor site and viral association
Presenter: Meagan Montesion
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
4113 - Toward the Standardization of Bioinformatics Methods for the Accurate Assessment of Tumor Mutational Burden (TMB)
Presenter: Han Chang
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
4468 - Prediction of primary resistance to anti-PD1 therapy (APD1) in 2nd line NSCLC
Presenter: Egbert Smit
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
4570 - Immunomodulatory germline variation impacts the development of multiple primary melanoma (MPM).
Presenter: Robert Ferguson
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
1169 - Leukocyte telomere length and recurrence risk after EGFR-TKIs therapy in patients with advanced lung adenocarcinoma
Presenter: Ming Yang
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
1707 - Gene embedding: a novel machine learning approach to identify gene candidates related to immunotherapy responsiveness
Presenter: Chi Tung Choy
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
2123 - Common and rare DPYD variants are predictive for 5FU/capecitabine (5FU) toxicity: The MRC COIN and COIN-B trials
Presenter: Ayman Madi
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract
5671 - The landscape of NTRK fusions in Chinese solid tumor patients
Presenter: Qi Ling
Session: Poster display session: Biomarkers, Gynaecological cancers, Haematological malignancies, Immunotherapy of cancer, New diagnostic tools, NSCLC - early stage, locally advanced & metastatic, SCLC, Thoracic malignancies, Translational research
Resources:
Abstract