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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

5434 - Adult medulloblastoma : an oncology radiation therapy department experience with 22 cases

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Topics

Radiation Oncology

Tumour Site

Central Nervous System Malignancies

Presenters

Mouna Kallel

Citation

Annals of Oncology (2018) 29 (suppl_8): viii122-viii132. 10.1093/annonc/mdy273

Authors

M. Kallel1, Z. Fessi1, W. Siala1, W. mnejja1, N. Fourati1, H. daoud1, T. Boudawara2, Z. Boudawara1, M. Frikha3, J. Daoud1

Author affiliations

  • 1 Radiation oncology, Habib Bourguiba hospital institute- Sfax, 3029 - Sfax/TN
  • 2 Pathology, Hopital Habib Bourguiba - Sfax University, 3029 - Sfax/TN
  • 3 Medical Oncology, Habib Bourguiba hospital institute- Sfax, 3029 - Sfax/TN
More

Resources

Abstract 5434

Background

Medulloblastoma is the most common central nervous system tumor in children. However, the occurrence in adults is rare and accounts for about 1% - 2%. The objective of this study is to define the clinical characteristic of this entity and therapeutic results.

Methods

We retrospectively evaluated the treatment data of 22 adult patients (≥18 years) treated for medulloblatoma from 1993 to 2013 in our department. Median follow up was 161.5 months [58; 296 months].

Results

Male female ratio was 2.14 :1. Median age was 25 years [18 ; 57]. Eight patients (36%) had cerebellar hemispheric tumors, nine cases (41%) occur in the vermis and five patients (23%) had an hemispheric-vermian localisation. Twenty one patients (95%) underwent macroscopically total exicision. Sixteen patients (73%) had classic form; five patients had desmoplastic (23%) type and one patient had extensive nodularity type. Patients were stratified into standard and high risk in 14 and 5 cases respectively. The risk couldn’t be identified for 3 patients. Among patients in the high-risk group, four received a cisplatin/etoposide chemotherapy before radiation. All patients had craniospinal radiotherapy. The mean interval between surgery and the begining of radiation therapy was 107 days. Craniospinal dose range between 30Gy and 36Gy. The dose in the posterior fossa was respectively 54Gy and 64Gy in 18 (82%) and 4 (18%) cases. The 5 year overall survival was 63%.

Conclusions

There are differences between pediatric and adult patients with medulloblastoma in terms of clinical and pathological characteristic. Ultimately, prospective trials including adult patient with medulloblastoma are needed to optimize the management of this rare and complex disease.

Clinical trial identification

Legal entity responsible for the study

Kallel Mouna.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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