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Proffered paper session - Haematological malignancies

2495 - A Revised International Prognostic Score System for Waldenström’s Macroglobulinemia


21 Oct 2018


Proffered paper session - Haematological malignancies




Annals of Oncology (2018) 29 (suppl_8): viii359-viii371. 10.1093/annonc/mdy286


M. GAVRIATOPOULOU1, E. Kastritis2, P. Morel3, A. Duhamel4, M.C. Kyrtsonis5, E. Durot4, A. Symeonidis6, K. Laribi7, E. Hatjiharisi8, L. Ysebaert9, A. Vassou10, N. Giannakoulas11, G. Merlini12, P. Repousis13, M. Varettoni14, E. Michalis15, B. Hivert16, M. Michalis17, V. Leblond14, M.A.C. Dimopoulos1

Author affiliations

  • 1 Oncology Department, Alexandra Hospital, 115 28 - Athens/GR
  • 2 Oncology Department, Alexandra Hospital, 11528 - ATHENS/GR
  • 3 Chu Amiens Picardie, Service D’hematologie Clinique Therapie Cellulaire, 80054 Amiens, France, Centre Hospitalier de Lens, 62300 - Lens/FR
  • 4 Univ. Lille, Chu Lille, Ea2694 – Santé Publique : épidémiologie Et Qualité Des Soins, F59000 Lille, France, Univ. Lille, CHU Lille, EA2694 – Santé publique : épidémiologie et qualité des soins, F59000 Lille, France, F59000 - LILLE/FR
  • 5 Hematology Deprtment, laikon hospital, 12345 - Athens/GR
  • 6 Hematology Deprtment, patras general hospital, 12368 - patras/GR
  • 7 Hematology Deprtment, HOSPITAL LE MANS, 1234 - Le Mans/FR
  • 8 Hematology Deprtment, IPPOKRATEION HOSPITAL, 34567 - THESSALONIKI/GR
  • 9 Hematology Deprtment, Institut Claudius Regaud - IUCT Oncopole, 31059 - Toulouse/FR
  • 10 Hematology Deprtment, general ioannina hospital, 152 32 - Chalandri/GR
  • 11 Hematology Deprtment, larissa general hospital, 12789 - larissa/GR
  • 12 Hematology Deprtment, PAVIA HOSPITAL, 123456 - PAVIA/IT
  • 13 Hematology Deprtment, METAKSA HOSPITAL, 34588 - Athens/GR
  • 14 French Innovative Leukemia Organization, French Innovative Leukemia Organization, 12345 - LILLE/FR
  • 15 Hematology Deprtment, genikon kratikon hospital, 3456 - Athens/GR
  • 16 French Innovative Leukemia Organization, French Innovative Leukemia Organization, 34567 - LILLE/FR
  • 17 Hematology Deprtment, leukosia general hospital, 12345 - leukosia/CY


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Abstract 2495


Waldenström’s Macroglobulinemia (WM) is an indolent disease with variable clinical presentation and heterogeneous prognosis. A robust and validated staging system was developed a decade ago, however, since then the treatment of the disease has changed. A revised staging system may better capture the prognosis of WM patients in the chemoimmunotherapy era.


We initially developed the revised system based on data from 492 patients included in the database of the Greek Myeloma Study Group with at least 3 years and a median of 7 years of follow up. An independent validation cohort included 229 symptomatic patients treated in institutions in France and Italy.


we identified that age (≤65 years vs 66-75 vs ≥ 76 years), b2-microglobulin ≥4 mg/L, serum albumin <3.5 gr/dl and LDH ≥250 IU/L can be used to stratify patients in 5 different prognostic groups and identify a very low risk group as well as a very high-risk group. The revised ISSWM identified groups with different outcomes interdependent of age, type of primary therapy or reason to initiate therapy. This simple staging system was further validated in an independent cohort.


A revised IPSSWM may improve patient risk stratification, is easily available and may be used in the everyday practice to provide prognostic information.

Clinical trial identification

Legal entity responsible for the study

The authors.


Has not received any funding.

Editorial Acknowledgement



All authors have declared no conflicts of interest.

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