Abstract 3069
Background
Skeletal muscle loss is a central component of cancer cachexia syndrome and is a poor prognostic factor in patients with cancer. We investigated prevalence of sarcopenia and the feasibility of exercise intervention in patients with newly diagnosed advanced solid cancer.
Methods
Between July 2017 and February 2018, consecutive patients with newly diagnosed advanced solid cancer were enrolled to our prospective cohort. Sarcopenia was defined as the third lumbar vertebra(L3) muscle index of less than 55 cm2/m2 for men and of less than 39 cm2/m2 for women. Patients were recruited to participate in a 12-week, combined resistance and aerobic exercise program consisted of supervised, hospital-based (2x/week) and home-based training (3x/week), during the first-line palliative chemotherapy. The primary endpoint were feasibility and safety of the exercise intervention. Pre- and post- exercise intervention skeletal muscle mass by bioelectrical impedance analysis(BIA) and patients’ quality of life questionnaires were measured and compared.
Results
Among 76 patients enrolled in the prospective cohort, sarcopenia was present in 58 (76.3%) patients (94.3% in men, 34.8% in women). Nineteen patients was enrolled in the exercise program, however 5 patients withdrew consent before commencement. Reasons for withdrawal were health concern (n = 2), distance to the hospital (n = 1) and unspecified (n = 2). The completion rate of the 12-week exercise program was 78.6% (11/14). Disease progression (n = 2) was the main reason for early discontinuation. The adherence rate of the supervised exercise session was 78.1% (207/265) and there was no adverse event associated with the exercise training. Among participants in the exercise program, there was no significant change in skeletal muscle index from baseline to post-intervention (mean, 9.4±1.3kg/m2 vs 9.4±1.2kg/m2, p = 0.982). FACIT-fatigue scale was non-significantly improved after the exercise intervention (mean, 35.2±10.4 vs 38.2±9.8, p = 0.635).
Conclusions
Exercise interventions appear to be feasible and safe in patients with advanced solid cancer and might have a role of preventing skeletal muscle loss without fatigue exacerbation during palliative chemotherapy.
Clinical trial identification
Legal entity responsible for the study
Gachon University Gil Medical Center.
Funding
National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (grant no. HA17C0045).
Editorial Acknowledgement
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
4942 - Analytical validation of OncoMasTR, a multigene test for predicting risk of distant recurrence in hormone receptor-positive early stage breast cancer
Presenter: Tony Loughman
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
5641 - Comparing the prognosis of favourable-histology breast cancers between younger women of less than 45 years of age at diagnosis with their older counterparts.
Presenter: Guek Eng Lee
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4448 - TNBC universe: a monocentric retrospective analyses of TILs and AR as prognostic markers
Presenter: Agnese Losurdo
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4755 - Genomic spectrum of Asian breast cancer based on targeted next-generation sequencing in 150 consecutive primary breast cancer
Presenter: Chihwan Cha
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
2741 - The Impact of the 21 Gene Recurrence Score (RS) on Chemotherapy (CHemoRx) Prescribing in Hormone Receptor (HR) Positive, Lymph Node Positive (LN+) Early-Stage Breast Cancer (BC) in Ireland: A National, Multi-centre, Prospective Study (CTRIAL-IE 15-34)
Presenter: Anees Hassan
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
3356 - Lymphocyte-predominant breast cancer has a significant lower mean of absolute neutrophil counts compared to non-lymphocyte-predominant breast cancer: Analyses with 576 cases
Presenter: Da Young Lee
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4020 - Genetic Alterations of Early-Stage Breast Cancers by next-generation sequencing (NGS)
Presenter: Yan Xu
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4924 - Oncotype Dx results in patients _40 years, Does age matters?: new insights
Presenter: Fernando Namuche
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
2646 - Impact of BRCA status on outcomes and survival in high-risk early breast cancers
Presenter: Elodie Klajer
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract
4516 - Early breast cancer classified as intermediate risk by the Prosigna assay: Characteristics and treatment strategy
Presenter: Nawale Hajjaji
Session: Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care
Resources:
Abstract