Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Poster Discussion session - Gynaecological cancers

2179 - A phase 2 trial of combination nivolumab and bevacizumab in recurrent ovarian cancer.


20 Oct 2018


Poster Discussion session - Gynaecological cancers


Cytotoxic Therapy;  Immunotherapy

Tumour Site

Ovarian Cancer


Joyce Liu


Annals of Oncology (2018) 29 (suppl_8): viii332-viii358. 10.1093/annonc/mdy285


J.F. Liu1, C. Herold1, W. Luo2, R. Penson3, N. Horowitz4, P. Konstantinopoulos1, C. Castro3, J. Curtis1, U.A. Matulonis1, S. Cannistra5, D.S. Dizon6

Author affiliations

  • 1 Medical Oncology, Dana Farber Cancer Institute, 02215 - Boston/US
  • 2 Biostatistics, Dana Farber Cancer Institute, 02215 - Boston/US
  • 3 Medical Oncology, Massachusetts General Hospital, 02115 - Boston/US
  • 4 Gynecologic Oncology, Dana Farber Cancer Institute, 02215 - Boston/US
  • 5 Medical Oncology, Beth Israel Deaconess Medical Center, Boston/US
  • 6 Medical Oncology, Lifespan Cancer Institute, Providence/US


Login to access the resources on OncologyPRO.

If you do not have an ESMO account, please create one for free.

Abstract 2179


Single-agent trials of immune checkpoint inhibitors against PD1 or PD-L1 have demonstrated only modest effect in ovarian cancer, suggesting that these drugs are not likely to be effective as monotherapy. VEGF has demonstrated immune-suppressive functions through mechanisms such as impairment of dendritic cell function and maturation. As a result, anti-VEGF therapy may enhance immunotherapeutic responses when combined with immune checkpoint inhibitors. We conducted this Phase 2 trial to investigate the combination of the anti-VEGF agent bevacizumab and the PD1 inhibitor nivolumab in women with recurrent ovarian cancer.


Women with epithelial ovarian, fallopian tube, or peritoneal cancer were eligible. Patients (pts) were required to have recurred within 12 months of their last dose of platinum-based chemotherapy; primary platinum-refractory disease was not allowed. All pts had measurable disease by RECIST 1.1. Prior bevacizumab was allowed unless there had been unacceptable toxicity. No prior treatment with drugs targeting T-cell co-stimulation or immune checkpoint pathways was allowed. All pts received bevacizumab 10mg/kg and nivolumab 240mg every 2 weeks until RECIST progression.


38 pts were enrolled. 20 pts were platinum sensitive (ie, PFI 6-12 months) and 18 pts were platinum resistant. There were no complete responses and 10 partial responses (PR, 8 confirmed, 2 unconfirmed). Of these PRs, 8 (6 confirmed, 2 unconfirmed) occurred in platinum sensitive pts and 2 (both confirmed) in platinum resistant pts. Three pts in each group have had stable disease of at least 6 months. The median progression free survival (PFS) for all pts was 9.4 months. The most common treatment-related adverse events included fatigue (15 pts, all Gr 1), AST elevation (7 pts; 6 Gr 1/2, 1 Gr 3), ALT elevation (6 pts; 5 Gr 1/2, 1 Gr 3), myalgia (6 pts; all Gr 1/2), and skin changes (6 pts; 5 Gr 1, 1 Gr 3). 3 pts had pneumonitis (2 Gr 2, 1 Gr 1) and 1 pt had colitis (Gr 1).


Combination nivolumab/bevacizumab demonstrated clinical activity in women with recurrent ovarian cancer, with an overall confirmed response rate of 21% and a median PFS of 9.4 months. Further studies of anti-angiogenic and immune checkpoint blockade combinations in ovarian cancer are warranted.

Clinical trial identification


Legal entity responsible for the study

Joyce Liu.


Bristol Myers Squibb.

Editorial Acknowledgement


R. Penson: Scientific Advisory boards: Genentech, Roche. P. Konstantinopoulos: Advisory boards: Merck, Pfizer, AstraZeneca. U.A. Matulonis: Consultant for Merck, Immunogen, 2x Oncology, Fujifilm, Geneos, Myriad Genetics. All other authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.