Abstract 1438
Background
Patients suffer from various oral complications in cancer treatments. Oral bacteria associate with the onset of dental focal infections and the progression of oral mucositis. Moreover, dental focal infections frequently associate with the onset of bacteremia, sepsis, and pneumonia systemically. The oral function degeneracy with these complications may become obstacle in cancer treatments. In Japan, the comprehensive oral management, including oral care and removal of dental focal infections, are performed in cancer patients. The aim of present study was to investigate the incidence of dental/oral complications in the cancer patients who underwent perioperative oral managements (POMs) based on large number of case series with a multicenter retrospective analysis.
Methods
In cancer patients who underwent POMs, medical records were reviewed and the incidence of oral complications and the efficacy of oral management were investigated retrospectively. This study protocol was approved by the Committee on Medical Research of Shinshu University (♯3639).
Results
Two thousand seven hundred and forty-four cancer patients underwent POMs (1,684 males and 1080 females, mean age 65.9±13.0 years) were investigated in this study. Among 2,744 patients, 2,097 patients (76.4%) started POMs before the initiation of cancer treatment, in which 2,130 patients (77.6%) underwent only oral care, and 391 patients (14.2%) invasive treatment such as tooth extraction. The incidence of dental focal infections during the period of cancer treatment was 8.2%. Acute periodontitis including alveolar abscess was most frequently seen (112 patients, 4.1%). The incidence of grade 2 and 3 oral mucositis was 2.8%. And the fever of unknown origin was seen in 113 patients (4.1%). Among them, dental focal infections were proved to be associated in 7 cases (6.2%). These incidences were thought to be lower than those of previously reports.
Conclusions
The efficacy of oral management in cancer patients might be suggested based on the analysis of large number of patients in this study. However, the further investigation is needed to establish the adequate oral management guideline in cancer patients.
Clinical trial identification
Nothing.
Legal entity responsible for the study
The Committee on Medical Research of Shinshu University.
Funding
Has not received any funding.
Editorial Acknowledgement
Nothing.
Disclosure
All authors have declared no conflicts of interest.