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Poster Discussion session - Haematological malignancies

5119 - A comparative study of 18F-FDG PET/CT with bilateral bone marrow trephine biopsy for assessment of bone marrow infiltration by lymphoma

Date

21 Oct 2018

Session

Poster Discussion session - Haematological malignancies

Topics

Staging and Imaging

Tumour Site

Lymphomas

Presenters

Durairaj Arjunan

Citation

Annals of Oncology (2018) 29 (suppl_8): viii359-viii371. 10.1093/annonc/mdy286

Authors

D. Arjunan1, G. Prakash2, P. Malhotra2, N. Varma2, S.C. Varma2, A. Das3, B.R. Mittal4, R. Basher4, D. Lad2, S. Kumari2, A.R. Khadwal2, S. Vikas2, S. Naseem5, A. Bal3

Author affiliations

  • 1 Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), 160012 - Chandigarh/IN
  • 2 Internal Medicine, PGIMER, 160012 - Chandigarh/IN
  • 3 Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), 160012 - Chandigarh/IN
  • 4 Nuclear Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), 160012 - Chandigarh/IN
  • 5 Hematology, Post Graduate Institute of Medical Education and Research (PGIMER), 160012 - Chandigarh/IN
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Resources

Abstract 5119

Background

Bone marrow trephine biopsy (BMTB) is the gold standard test for identification of marrow infiltration by lymphoma. Literature supports the use of bilateral iliac crest biopsy for appropriate staging of lymphoma.18F-FDG PET/CT has an advantage of evaluating the entire skeleton for bone or bone marrow (BM) uptake. We calculated the predictive values of PET/CT in detecting the BM infiltration in lymphoma patients. We also assessed the increment in the yield of bilateral BMTB over unilateral BMTB in detecting BM infiltration by lymphoma.

Methods

This study is a retrospective and prospective single center observational study done in tertiary care hospital in Chandigarh, India. The study included 230 newly diagnosed lymphoma patients who underwent both baseline staging PET CT and staging bilateral Bone Marrow Trephine Biopsy (BMTB). The bone marrow trephine biopsy slides were reviewed independently by two experienced pathologists (one hematopathologist and one histopathologist).

Results

Table: 1013PD

The sensitivity, specificity, PPV and NPV of 18-FDG PET/CT in detecting BM infiltration in patients with lymphoma

DiagnosisSensitivitySpecificityPPVNPV
All Subtypes59%65%38%81%
HL81%58%31%93%
NHL54%67%40%77%
HG-NHL58%62%35%81%
LG-NHL43%84%63%70%

The incremental yield of diagnosing BM infiltration by lymphoma by doing bilateral posterior superior iliac spine biopsies over unilateral biopsy was 25% for all subtype of lymphoma and 57% for HL. The most common pattern of BM infiltration was nodular (37%), followed by diffuse (22%), para-trabecular (21%) and interstitial (20%) in the whole study cohort. There was a strong aggreement between the two pathologists in reporting BMTB. The accuracy of SUVmax in differentiating patients with and without true BM involvement in our study cohort was less than optimal.

Conclusions

Opting for unilateral trephine biopsy for lymphoma staging may lead to inadvertent under-staging, especially in Hodgkin Lymphoma. We may consider avoiding bone marrow biopsy in patients with Hodgkin Lymphoma with no FDG avid skeletal lesions in PET/CT. The BMTB has got a high reproducibility and lesser inter observer variability in detection of bone marrow infiltration by lymphoma.

Clinical trial identification

Legal entity responsible for the study

PGIMER, Chandigarh.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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