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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

3158 - Significance of receptors expression, mitotic index and Ki67 in breast cancer patients with Nottingham Prognostic Index (NPI) poor prognosis score

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

Mejri Nesrine

Citation

Annals of Oncology (2018) 29 (suppl_8): viii58-viii86. 10.1093/annonc/mdy270

Authors

M. Nesrine1, H. El Benna1, Y. Berrazegua1, S. Labidi1, N. Daoud1, H. Boussen2

Author affiliations

  • 1 Medical Oncology, Abderrahmen Mami Hospital, 2080 - Ariana/TN
  • 2 Department Of Medical Oncology, Hopital Abderrahman Mami, Ariana/TN
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Resources

Abstract 3158

Background

Nottingham Prognostic Index (NPI) is a used prognostic model for breast cancer patients, but new histological prognostic factors are today defined. We evaluated their effect within patients with poor prognosis NPI score.

Methods

We retrospectively selected 351 non-metastatic breast cancer patients with High NPI score (>5,4). They were classified according to surrogate definition of intrinsic subtypes of breast cancer (St Gallen 2015). Several prognostic factors were evaluated. We used log rank test, cox regression model to evaluate the significance of clinic-pathological factors.

Results

Median age of our population was 50 years. They were luminal A in 30%, Luminal B in 43%, HER overexpression in 10% and basal like in 17%. On univariate analysis, menopausal status (HR = 0,32 [0.13-0,76]), endocrine receptors expression (HR = 6,52 [2,57-16,54]), HER2 expression (HR = 3,08 [0.191-10.39]), Mitotic index (HR = 1,05 [1,02-1,09]) and obesity (HR = 3,49 [1,27-9,58]) were significant prognostic factors. There was no prognostic value of age<35 years, Ki 67 cut-off of 20% and nodal capsule rupture. There was a highly significant difference (p < 0.0001) in overall survival between the 4 intrinsic subtypes. Five-year overall survival was 95% for Luminal A, 90% for Luminal B, 56% for HER2 and 36% for basal-like. On multivariate analysis receptors expression and intrinsic subtype were significantly associated to survival (p < 0.05).

Conclusions

In NPI aggressive disease, the most important prognostic factors were receptors expression and intrinsic subtype. The elaboration of a histology-matched NPI score could afford better prognostic evaluation of early stage breast cancer.

Clinical trial identification

Legal entity responsible for the study

Abderrahmen Mami Hospital, Medical Oncology Department.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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