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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

3647 - Real-life data on the cardiac toxicity of adjuvant fixed-dose subcutaneous trastuzumab in HER2-positive breast cancer.

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

Rita De Sanctis

Citation

Annals of Oncology (2018) 29 (suppl_8): viii58-viii86. 10.1093/annonc/mdy270

Authors

R. De Sanctis1, F. D'Antonio1, E. Agostinetto1, A. Marinello1, G. Masci1, M. Zuradelli1, A. Losurdo1, D. Guiducci2, C. Tinterri3, A. Testori3, W. Gatzemeier3, V. Errico3, R. Torrisi1, A. Santoro1

Author affiliations

  • 1 Medical Oncology And Hematology, Humanitas Cancer Center, Istituto Clinico Humanitas, 20089 - Rozzano (Milan)/IT
  • 2 Cardiology, Humanitas Cancer Center, Istituto Clinico Humanitas, 20089 - Rozzano (Milan)/IT
  • 3 Breast Surgery, Humanitas Cancer Center, Istituto Clinico Humanitas, 20089 - Rozzano (Milan)/IT
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Resources

Abstract 3647

Background

Fixed-dose adjuvant subcutaneous (s.c.) trastuzumab (T) has been approved in the treatment of early HER2-positive breast cancer (BC), based on the evidence of its non-inferiority to standard intravenous (i.v.) infusion. Few data from real-life are available regarding cardiac toxicities associated with fixed-dose subcutaneous T administration. We conducted a retrospective study in order to compare cardiac toxicity profile of adjuvant fixed-dose s.c.-T and weight-based i.v.-T, according to anthropometric data which takes into account more than simply weight.

Methods

Patients treated with adjuvant T for HER2-positive breast cancer at Humanitas Research Hospital from December 2013 to October 2017 were evaluated. T was administered at a either fixed dose of 600 mg s.c. or 6 mg/kg i.v, respectively. Data regarding previous chemotherapy, Body Mass Index (BMI), and development of cardiotoxicity (decrease in LVEF >10% points, to a value < 50%) were extracted from medical records. Four BMI classes were considered: underweight (BMI < 18 kg/sqm), normal weight (18-24.9 kg/sqm), overweight (25-29.99), and obesity (≥30). All variables were compared with categorical tests (Pearson Chi-squared with Yates correction or Fisher exact test).

Results

A total of 260 HER2-positive BC patients receiving adjuvant T were analyzed. Median age was 56 (range, 32-88), median BMI 23.5 (range, 15.8-50.2 kg/sqm). 196 (75.38%) patients received s.c.-T and 64 (24.62%) i.v.-T. 156 had a normal weight, while 11 were underweight, 54 overweight and 39 obese. The incidence of cardiotoxicity was not different among the BMI classes according to the route of administration of T (p = 0.28). In the subset of the patients who had developed cardiac toxicity, BMI did not result as a risk factor, as well as a previous treatment with anthracyclines (p = 0.89).

Conclusions

Cardiac toxicity profile of fixed-dose s.c.-T is consistent with that of weight-based i.v.-T in the real-world setting regardless differences in anthropometric data as BMI. Our study confirms safety of subcutaneous T administration, which still represents a valid and more convenient alternative to intravenous administration.

Clinical trial identification

Legal entity responsible for the study

Istituto Clinico Humanitas.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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