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Preliminary results of the first-in-human (FIH) study of MK-1454, an agonist of stimulator of interferon genes (STING), as monotherapy or in combination with pembrolizumab (pembro) in patients with advanced solid tumors or lymphomas

Date

20 Oct 2018

Session

Poster Discussion session - Developmental therapeutics / investigational immunotherapy

Presenters

Kevin Harrington

Authors

K.J. Harrington1, J. Brody2, M. Ingham3, J. Strauss4, S. Cemerski5, M. Wang6, A. Tse5, A. Khilnani5, A. Marabelle7, T. Golan8

Author affiliations

  • 1 Radiotherapy & Imaging, The Royal Marsden/Institute of Cancer Research National Institute for Health Research Biomedical Research Centre, SW3 6JB - London/GB
  • 2 Hematology-oncology, The Mount Sinai Hospital, New York/US
  • 3 Medical Oncology, Columbia University Medical Center, New York/US
  • 4 Oncology, Mary Crowley Medical Research Center, 75230 - Dallas/US
  • 5 Medical Oncology, Merck & Co., Inc., Kenilworth/US
  • 6 Biostatistics, Merck & Co., Inc., Kenilworth/US
  • 7 Drug Development Department, Gustave Roussy, 94805 - Villejuif/FR
  • 8 Oncology, Chaim Sheba Medical Center, 52621 - Ramat Gan/IL
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Resources

Background

The STING pathway has been implicated in antitumor immunity and response to immune checkpoint inhibitors. Intratumoral (IT) administration of MK-1454, a cyclic dinucleotide STING agonist, results in complete tumor regression and enhances the efficacy of anti-PD1 therapy in mouse syngeneic models. Initial results of the MK-1454 FIH study as monotherapy (Arm 1) or in combination with pembro (Arm 2) in pts with solid tumors or lymphomas are presented.

Methods

A phase 1, open label, multicenter, dose escalation study. Eligible pts had ≥1 measurable-injected and -noninjected lesions. MK-1454 was given IT q1wk x 9 for 3 cycles then q3wk thereafter; dose escalations were 10−3000 ug (Arm 1) and 90−1500 ug (Arm 2) using accelerated titration followed by mTPI design. Pembro was given at 200 mg IV q3wk. Arm 1 pts who progressed were eligible to crossover (n=9) to Arm 2. Study objectives included evaluation of safety, tolerability, PK/PD and tumor responses (RECIST v1.1).

Results

As of Jul 31, 2018, 26 pts in Arm 1 and 34 in Arm 2 were treated. DLTs at 1500 ug were vomiting (1 pt, Arm 1) and injection site reactions (2 pts, Arm 2). An MTD has not been determined; dose escalation is ongoing. Treatment related adverse events (TRAEs) occurred in 83% and 82% of pts in Arms 1 and 2, 9% and 14% were grade ≥3 AEs, and resulted in discontinuation of 7% of pts in Arm 2 (0% in Arm 1); no deaths due to TRAEs occurred. Most common TRAEs in ≥10% of pts in Arms 1 and 2 included pyrexia, chills, fatigue, injection site pain, and nausea (Arm 1) and pruritus (Arm 2). In both arms, dose dependent increases in systemic MK-1454 exposure (t1/2 ≈1.5 hr) and elevations in serum cytokines IL-6 and IP-10 and STING induced gene expression in blood were observed. Of 25 pts (first dosed by May 01, 2018) in Arm 2, 6 (24%) PRs were seen (3 HNSCC, 1 TNBC, 2 anaplastic thyroid carcinoma) with reductions in both target-injected and -noninjected lesions (median -83%); no CR/PR in Arm 1 were observed. DCR was 20% (Arm 1) and 48% (Arm 2).

Conclusions

Combined MK-1454 plus pembro resulted in encouraging efficacy and an acceptable safety profile supporting continued development of the combination regimen.

Clinical trial identification

Clinical trial identification: ClinicalTrials.gov number NCT03010176; originally posted January 4, 2017

Editorial Acknowledgement

Joanne Tomassini, Merck & Co., Inc., Kenilworth, NJ, USA

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