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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

1792 - Palliative Local Therapy of advanced Breast Cancer

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

Tamar Letodiani

Citation

Annals of Oncology (2018) 29 (suppl_8): viii603-viii640. 10.1093/annonc/mdy300

Authors

T. Letodiani1, M. Shavdia2, N. Shavdia3, K. Chaava2, N. Gegeshidze2

Author affiliations

  • 1 Palliative Care, National Cancer Center of Georgia (NCCG), 177 - Tbilisi/GE
  • 2 Paliative Care, Tbilisi state medical university, 0177 - Tbilisi/GE
  • 3 Palliative Care, JSC "Neo Medi", 159 - Tbilisi/GE
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Resources

Abstract 1792

Background

Objective: Initial nidus tumor infiltration is often revealed in patients with advanced breast cancer. In such cases, all treatment is focused on improvement of the quality of life.

Methods

Special mixture of Linimentam Synthomycin 10% (25 gr) + Tegafur (Ftorafur) 800 mg was prepared for anti inflammatory and tumor therapy. The mixture was used in bandaging of breast tumor infiltration in 99 patients for 10 days (interval - 20 days). Tumor infiltration in 84 patients -15 cm, in 15 patients > 30 cm. In 3 cases double-sided process was observed. All the patients had low hematological indicator and KPS (40,0 %).

Results

After II course of treatment: significant improvement of dynamics of tumor infiltration in 49 (49,5%) patients (reduction of hyperemia, pain syndrome, itching, temperature, etc). After the III-IV courses: wound cleansing from purulent, formation of granulation areas and improvement of the quality of life in 10 patients (Tumor reduction and full epithelization in 10 (10,1%) patients enabling sanitation of mastectomy). Worsening of condition - in 18 (18.2%), stabilization in 71 (71.7%) patients. After the IV course of local therapy tumor infiltration was reduced by 9 cm in average (Maximum effect was seen in patients with infiltration of 15 cm) KPS average indicator improved from 40,0% to 53,4% (p < 0,05).

Conclusions

1. Administration of Synthomycin 10% (25 gr) + Tegafur (Ftorafur) 800 mg for local chemotherapy and anti – inflammatory therapy of breast cancer tumor infiltration contributes to reduction of hyperemia, temperature reaction, itching, suppuration, size of nidus, pain syndrome and accordingly improvement of the quality of life (KPS has improved from 40,0% to 53,4%; 2. Practically there are no side effects upon a local chemotherapy of breast.

Clinical trial identification

Legal entity responsible for the study

Tbilisi State Medical University (Georgia).

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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