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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

3356 - Lymphocyte-predominant breast cancer has a significant lower mean of absolute neutrophil counts compared to non-lymphocyte-predominant breast cancer: Analyses with 576 cases

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

Da Young Lee

Citation

Annals of Oncology (2018) 29 (suppl_8): viii58-viii86. 10.1093/annonc/mdy270

Authors

D.Y. Lee1, S.E. Park2, C. Cha2, C. Yoon2, S.J. Bae2, S.G. Ahn2, J. Jeong2

Author affiliations

  • 1 Department Of Surgery, Gananam Severance Hospital, 135-720 - Seoul/KR
  • 2 Department Of Surgery, Gananam Severance Hospital, Seoul/KR
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Resources

Abstract 3356

Background

Tumor-infiltrating lymphocytes (TILs) in surgical-specimen might be associated with host-cell mediated immunity, which could be partly reflected by blood cell counts from peripheries. We investigated whether peripheral blood cell counts are associated with TILs in 577 patients with breast cancer.

Methods

Between August 2016 and April 2018, we evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery according to standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥ 50%). Blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC), percentages of ANC and ALC, and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data.

Results

Of 577 tumors, 99 (17.2%) was LPBC, and 478 (82.8%) was non-LBPC. When 5 markers of peripheral blood counts were compared, LPBC had a significantly higher mean ANC than non-LPBC (3,671 vs. 3,336; P = 0.004), but other means were not different. Further, in luminal/HER2-negative breast cancer, mean ANC of LPBC was still higher than that of non-LPBC (P = 0.025), whereas it tended to be higher in LPBC in other subtypes (P = 0.385 in HER2, P = 0.260 in TNBC).

Conclusions

Our results suggest that low peripheral ANC might be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with tumor-immune microenvironment. Further study on an association between peripheral ANC and tumor-associated neutrophil consisting tumor micromileu is warranted.

Clinical trial identification

Legal entity responsible for the study

The Institutional Review Boards of the Gangnam Severance Hospital, Yonsei University, Seoul, Korea.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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