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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

2825 - Intratumoral heterogeneity on dedicated breast positron emission tomography before chemotherapy predicts the outcome of neoadjuvant chemotherapy in breast cancer

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

norio masumoto

Citation

Annals of Oncology (2018) 29 (suppl_8): viii87-viii89. 10.1093/annonc/mdy271

Authors

N. masumoto1, T. Kadoya2, E. Suzuki2, S. Sueoka2, N. Goda2, S. Sasada1, A. Emi2, R. Haruta2, T. Kataoka2, M. Okada1

Author affiliations

  • 1 Surgical oncology, Hiroshima University, 734-8551 - Hiroshima/JP
  • 2 Breast Surgery, Hiroshima University Hospital, 734-8551 - Hiroshima/JP
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Resources

Abstract 2825

Background

Dedicated breast positron emission tomography (DbPET) can detect intratumoral heterogeneity using 18F-fluorodeoxyglucose (FDG). We have proved that intratumoral heterogeneous distribution of FDG on DbPET was significantly related with high nuclear grade and high Ki-67 proliferation index (Breast Cancer Res Treat 2018; 171:315–23). We aimed to evaluate whether intratumoral heterogeneous distribution of FDG on DbPET can predict the effects of neoadjuvant chemotherapy (NAC) on breast cancer.

Methods

We evaluated 58 consecutive patients with breast cancer who underwent DbPET before NAC concurrently between August 2016 and March 2018. The relationships between the pathological response for NAC and the maximum standard uptake values (SUVmax) of DbPET, including estrogen receptor (ER) and human epidermal growth factor receptor type-2 (HER2) statuses, and the intratumoral heterogeneous distribution of FDG on DbPET, were evaluated.

Results

Breast cancer with intratumoral heterogeneous distribution of FDG on DbPET showed a tendency to be related with pathological complete response (pCR) (Table). The SUVmax of DbPET showed an increasing tendency with intratumoral heterogeneous distribution. ER positive-breast cancer with intratumoral heterogeneous distribution showed a tendency to be related with pCR.Table: 278P

Relation between biological factors and pathological response

pCRNon-pCRp
Grade0.17
1–2310
32025
Ki-670.35
< 20%14
≥ 20%2231
ER0.07
positive1524
negative811
HER20.06
positive1311
negative1024
DbPET, intratumoral distribution0.23
Heterogeneity1924
Homogeneity411

Conclusions

The SUVmax of DbPET associates with intratumoral heterogeneous distribution. In addition, intratumoral heterogeneity on DbPET provides predictive value for achieving pCR on ER positive-breast cancer and might inform therapeutic decisions.

Clinical trial identification

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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