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Poster Discussion session -Gastrointestinal, non-colorectal

2665 - Influence of enteral nutrition on nutritional status, treatment toxicities, and short-term outcomes in esophageal carcinoma patients treated with concurrent chemoradiotherapy: a prospective, multicenter, randomized controlled study

Date

19 Oct 2018

Session

Poster Discussion session -Gastrointestinal, non-colorectal

Presenters

Tao Li

Citation

Annals of Oncology (2018) 29 (suppl_8): viii205-viii270. 10.1093/annonc/mdy282

Authors

T. Li1, J. Lyu1, G. Zhu2, J. Li3, R. Zhao4, S. Zhu5, J. Wang6, L. Xing7, D. Yang8, C. Xie9, L. Shen10, H. Shi11, J. Lang1

Author affiliations

  • 1 Department Of Radiotherapy, Sichuan Cancer Hospital&institute, 610042 - Chengdu/CN
  • 2 Department Of Radiotherapy, China-Japan Friendship Hospital, 100142 - Beijing/CN
  • 3 Department Of Radiotherapy, Shanxi Cancer Hospital, 030013 - Taiyuan/CN
  • 4 Department Of Radiotherapy, General Hospital of NingXia Medical University, 750004 - Yinchuan/CN
  • 5 Department Of Radiotherapy, Fourth Hospital Of Hebei Medical University, 050035 - Shijiazhuang/CN
  • 6 Department Of Radiotherapy, Henan Cancer Hospital, 450008 - Zhengzhou/CN
  • 7 Department Of Radiotherapy, Shandong Cancer Hospital, 100142 - Beijing/CN
  • 8 Department Of Radiotherapy, First Affiliated Hospital Of Zhengzhou University, 450052 - Zhengzhou/CN
  • 9 Department Of Radiotherapy, Zhongnan Hospital Of Wuhan University, 430071 - Wuhan/CN
  • 10 Department Of Radiotherapy, Xiangya Hospital Central South University, 410008 - Changsha/CN
  • 11 Surgery, Beijing Center Century Altar Hospital Affiliated to the Capital Medical University, 100142 - Beijing/CN
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Resources

Abstract 2665

Background

To investigate the influence of enteral nutrition on body weight, nutritional status, treatment toxicities, and short-term outcomes in esophageal carcinoma patients with concurrent chemoradiotherapy (CCRT).

Methods

Eigible patients were randomly assigned (2:1 ratio) to EN group or control group. The primary endpoint was the change in body weight from baseline after treatment. The secondary endpoints were nutrition related blood parameter changes, treatment toxicities and outcomes.

Results

Between Mar. 2015 and Jun. 2017, 222 patients from ten hospitals were randomised into the EN group (n = 148) and the control group (n = 74). Patients in EN group lost less body weight compared with the control group (P<.0.05). Participants who received EN had less decline than controls in serum albumin and hemoglobin (P < 0.05). There was no difference in total lymphocyte counts in the two groups. Grade 3/4 leukopenia and infection rates were significantly more frequent in the control group than in the EN group (P < 0.05). Radiation pneumonitis and esophagitis tended to be less frequent in the EN group, albeit insignificantly. Patients supported on EN experienced greater chemoradiotherapy completion rates. There was no significant difference in tumor response between two groups (P > 0.05).

Conclusions

Enteral nutrition can reduce the weight loss of esophageal cancer patients during chemoradiotherapy, improve nutritional status, treatment tolerance, reduce toxicity.

Clinical trial identification

NCT 02399306.

Legal entity responsible for the study

Tao Li.

Funding

Has not received any funding.

Editorial Acknowledgement

none

Disclosure

All authors have declared no conflicts of interest.

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