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Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

1833 - Expression of Sp17 and its association with clinicopathological parameters of breast cancer

Date

22 Oct 2018

Session

Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care

Presenters

Yu-ting Zhou

Citation

Annals of Oncology (2018) 29 (suppl_8): viii87-viii89. 10.1093/annonc/mdy271

Authors

Y. Zhou

Author affiliations

  • Breast Department, West China Hospital, Sichuan University, 610041 - Chengdu/CN
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Resources

Abstract 1833

Background

Sperm protein 17 (Sp17) was found to be only expressed in breast cancer and not the normal breast tissue. Although Sp17 antibody can effectively inhibit the growth of human cancer cells, suggesting a potential therapeutic target, the role of Sp17 in tumor remains unclear. Hence, we examined the expression status of Sp17 in breast cancer and analyzed the correlation between Sp17 expression and clinicopathological parameters of breast cancer. We then proceeded to assess whether the expression of Sp17 has any effect on patient prognosis.

Methods

Quantitative real-time PCR and immunohistochemistry were conducted to test expression rate of Sp17 mRNA and protein in breast cancer samples, respectively. Clinicopathological parameters of each patient were collected by reviewing medical records. Reliable follow-up information was obtained via phone call. Kaplan–Meier regression was conducted for survival analysis. Univariate and multivariate analyses were used to identify the variables associated with Sp17 expression.

Results

We studied 100 primary breast cancer and 20 normal breast specimens. Sp17 was expressed in 27% of breast cancer samples. The difference between expression and non-expression of Sp17 was statistically significant in disease-free survival and overall survival. Lymph node metastasis and molecular subtyping were independent factors associated with Sp17 expression.

Conclusions

Our findings suggest a role for Sp17 in tumor metastasis and aggressiveness. Whether Sp17 can be used as a prognostic marker for breast cancer will require a study of a larger sample size.

Clinical trial identification

Legal entity responsible for the study

The Ethics Committee of the Sichuan University.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

The author has declared no conflicts of interest.

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