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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

3731 - Effect of the polymorphism rs2470893 of the CYP1A1 gene on ovarian and endometrial cancer in Mediterranean women

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Presenters

Judith Begona Ramirez Sabio

Citation

Annals of Oncology (2018) 29 (suppl_8): viii1-viii13. 10.1093/annonc/mdy268

Authors

J.B. Ramirez Sabio1, J.V. Sorlí2, R. Barragán2, F. Rebeca2, E.M. Asensio2, D. Corella2

Author affiliations

  • 1 Medical Oncology, Hospital de Sagunt, 46520 - Sagunt/ES
  • 2 Preventive Medicine Department And Ciber Fisiopatología De La Obesidad Y Nutrición, Universitat de València, 46010 - Valencia/ES
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Resources

Abstract 3731

Background

The CYP1A1 gene is located on chromosome 15 (15q22-q24.1) and is part of the cytochrome P450 family. This catabolizing enzyme has an important role in the activation / deactivation of various chemical agents, including xenobiotics and sex hormones. It is related to the synthesis of cholesterol and steroids, and to the metabolism of drugs, coffee, or different metabolites such as those of tobacco. It is found mainly in extrahepatic tissues such as lung, breast or ovarian follicles, and participates in the metabolism of a large number of xenobiotics as well as one of endogenous substrates. Human cytochrome P450 1A 1 is one of the most important enzymes involved in the human carcinogenesis because it metabolizes several procarcinogens to active carcinogens. There are previous studies that have linked rs2470893 with ovarian cancer. Our aim has been to estimate the association between polymorphism rs2470893 of the CYP1A1 gene on ovarian and endometrial cancer in a Mediterranean population.

Methods

We have carried out an observational study at baseline and longitudinally in the PREDIMED-Valencia study including 696 women at high cardiovascular risk. We prospectively analyzed cancer incidence as a secondary outcome in this study. Lifestyle, clinical and biochemical variables were assessed by standardized methods. DNA was isolated from blood and the selected polymorphisms were determined

Results

We detected 8 new cases of ovarian and endometrial cancer from 2003 to 2014, representing 0.6% and 0.1% respectively, of all cancers. In our study it was observed that the variant rs2470893 was related to ovarian and endometrial cancer. The allelic frequency of the A allele was 0.246. The carriers of the G allele were grouped in front of the AA carriers. When assessing the risk of having suffered from ovarian or endometrial cancer according to the genotype of this variant, it was observed that the individuals carrying the AA allele presented a higher risk OR = 8.7: CI 95% (2.4-31.9); P = 0.001 after adjustment for age, intervention group, tobacco smoking and obesity (BMI ≥ 30 Kg/m2).

Conclusions

rs2470893of the CYP1A1 gene could be associated with ovarian and endometrial cancer in a high cardiovascular risk population.

Clinical trial identification

ISRCTN35739639.

Legal entity responsible for the study

University of Valencia.

Funding

Instituto de Salud Carlos III.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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