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Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

1877 - Correlation beetween the expression of androgens receptor (RA) and histopathological characteristics and survival parameters of breast cancer

Date

21 Oct 2018

Session

Poster display session: Basic science, Endocrine tumours, Gastrointestinal tumours - colorectal & non-colorectal, Head and neck cancer (excluding thyroid), Melanoma and other skin tumours, Neuroendocrine tumours, Thyroid cancer, Tumour biology & pathology

Presenters

Irene Sillero

Citation

Annals of Oncology (2018) 29 (suppl_8): viii670-viii682. 10.1093/annonc/mdy304

Authors

I.D. Sillero1, A. López González2, L.F. Sanchez Cousido2, M. López-Flores2, E. Honrado Franco3, L. Lopez Gonzalez4, O. Sanz5, C. Castañón López2, A. García Palomo2

Author affiliations

  • 1 Oncología Médica, Complejo Asistencial Universitario de León, 28002 - León/ES
  • 2 Oncología Médica, Complejo Asistencial Universitario de León, León/ES
  • 3 Pathology, Complejo Asistencial Universitario de León, León/ES
  • 4 Radiology, Complejo Asistencial Universitario de León, León/ES
  • 5 General Surgery, Complejo Asistencial Universitario de León, León/ES
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Resources

Abstract 1877

Background

Clinical trials have attempted to demonstrate a correlation between the expression of androgen receptor (RA) and the prognosis of breast cancer. We have analyzed a sample of women with diagnosis of triple negative breast cancer (TN) in order to establish their prognostic value.

Methods

We retrospectively analyzed a cohort of women diagnosed of early stage TN breast cancer in the Universitary Hospital of León from 2008 to 2013. Our first end point was to establish a correlation between RA expression, clinical parameters, immunohistochemical characteristics and PFS and OS.

Results

A total of 58 women with TN breast cáncer were included. From the total number of biopsies, 20% expressed RA, and the 80% of this subgroup had an apocrine histology. The RA expression was associated to a favourable grade (G) :( RA + G3: 45.5% vs. RA - G3 79%, p = 0.05); smaller size (11.1% T1, 77% T2 .11.1% T3-T4), and lower percentage of Ki-67: (mean in RA + 23.6% ± 5 vs 41.4% ± 3, p = 0.005). There was also a trend towards association with premenopausal status (60% vs 40% postmenopausal p = 0.02) and axillary involvement at the time of diagnosis (65% N1-2 vs. 35% N0 p = 0.045). Regarding OS and PFS, we did not find statistical significant differences between RA positive and negative tumors (p = 0.89 and p = 0.34 respectively).

Conclusions

The RA expression in TN breast cancer is associated with more favourable histopathological characteristics except the axillary involvement. Although most of our cases were N+, we did not find a worse prognosis in these patients. It is possible that with the antiandrogenic therapy a better survival could be obtained, which would justify the design of clinical trials.

Clinical trial identification

Legal entity responsible for the study

CAULE.

Funding

Has not received any funding.

Editorial Acknowledgement

Disclosure

All authors have declared no conflicts of interest.

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